PMID: 6977615Apr 1, 1982Paper

Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies

The Journal of Experimental Medicine
D L SacksA Sher

Abstract

Anti-idiotypic (anti-Id) antibodies were raised against three protective monoclonal antibodies, each with specificity for the variable antigen type (VAT) of a clone of Trypanosoma rhodesiense. The IgG1 fractions of each were pooled and administered to BALB/c mice 3-4 wk before homologous challenge. The course of primary parasitemia was altered in 19 of 30 anti-Id-treated animals. The immunity was manifested as either: (a) complete protection, (b) reduced parasitemia, or (c) selection against parasites bearing the original VAT. The three idiotypes (Id) were found in variable levels in serum during the course of infection in control animals. However, in all anti-Id-treated mice that displayed immunity, one Id in particular (7H11) was detectable much earlier in infection and in higher levels than in control mice or anti-Id-treated, nonimmune mice. Six of nine mice treated with the anti-7H11 Id alone also displayed immunity, manifested in this case exclusively as selection against parasites bearing the original VAT. The effect was again associated with the more rapid appearance of the Id after infection. Specificity of the anti-Id-induced immunity was supported by the failure of anti-7H11 Id treatment to alter the course of infecti...Continue Reading

References

Nov 1, 1975·The Journal of Experimental Medicine·E Trenkner, R Riblet
Jul 1, 1978·European Journal of Immunology·M H JuliusA A Augustin
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P A Cazenave
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J UrbainC Collignon
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L Olsson, H S Kaplan
Jan 1, 1980·Immunological Reviews·G KelsoeK Rajewsky
Oct 1, 1975·European Journal of Immunology·K Eichmann, K Rajewsky

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·G T Nepom, K E Hellström
Jan 1, 1986·Archives of Virology·K C McCullough
Jan 1, 1992·International Journal of Clinical & Laboratory Research·T C ChanhJ F Hewetson
Sep 1, 1982·Indian Journal of Pediatrics·A K Abbas
Dec 1, 1992·International Journal for Parasitology·N C Smith
Jan 1, 1995·International Journal for Parasitology·R BardonC Aguila
Apr 8, 1991·Journal of Immunological Methods·A Altamirano-BustamanteF Kohen
Jan 1, 1988·Developmental and Comparative Immunology·A R Arulanandam, R A Goldsby
Dec 1, 1987·Veterinary Immunology and Immunopathology·R A GoldsbyA J Guidry
Dec 1, 1987·Veterinary Immunology and Immunopathology·H Wigzell
Apr 1, 1994·Veterinary Immunology and Immunopathology·S DandapatG C Mohanty
Aug 1, 1983·Journal of Virological Methods·R C Kennedy, G R Dreesman
Jan 1, 1987·Immunology Today·M ZanettiJ Salk
Mar 1, 1985·Vaccine·K C McCullough, D Langley
Jul 1, 1987·Veterinary Parasitology·P K Murray
Jan 1, 1989·Medical Hypotheses·N Godin
Sep 1, 1988·Journal of the American Academy of Dermatology·M J Rico, R P Hall
Apr 13, 1999·Infectious Disease Clinics of North America·P S Hefty, R C Kennedy
Oct 16, 1999·Scandinavian Journal of Immunology·H Lemke, H Lange
Feb 21, 1985·The New England Journal of Medicine·A H Sharpe, B N Fields
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·H KoprowskiH F Sears
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·H C Ertl, R W Finberg
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G T NepomK E Hellström
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G Parisi
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R BillettaM Zanetti
Jun 1, 1988·The Journal of Experimental Medicine·V H Van CleaveD W Metzger
Aug 18, 2004·Hybridoma and Hybridomics·Tuba YildirimI Yavuz Sezen
Mar 1, 1993·American Journal of Reproductive Immunology : AJRI·V Khole, U C Hegde
Nov 1, 1987·The Journal of Clinical Investigation·R C KennedyC A Bona
Mar 1, 1989·The Journal of Clinical Investigation·T F Kresina, G R Olds
Dec 1, 1988·European Journal of Epidemiology·L Polonelli, G Morace
Jan 1, 1991·Critical Reviews in Microbiology·L PolonelliG Morace
Jan 1, 1986·International Reviews of Immunology·G N Gaulton, M I Greene
Jan 1, 1986·International Reviews of Immunology·R C Kennedy, G R Dreesman

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