Immunization of mice by intracutaneous inoculation with viable virulent Cryptococcus neoformans: immunological and histopathological parameters.

Infection and Immunity
S A MoserJ E Williams

Abstract

Immune responses, including protection and delayed hypersensitivity, were evaluated in experimental murine cryptococcosis. Mice were immunized by the intracutaneous inoculation of viable virulent Cryptococcus neoformans yeasts. Response to the cutaneous infection was evaluated histologically and by cultural assays of the internal organs, as well as by intravenous challenge with the same strain. Protection was assessed by survival, histopathology, and quantitative organ culture. The intracutaneous inoculation of cryptococci resulted in a local inflammatory response that effectively limited dissemination of the organisms systemically and induced the development of delayed hypersensitivity demonstrable with a membrane extract of C. neoformans and with soluble cytoplasmic substances. A protective response was induced by the cutaneous inoculation of cryptococci as well, in that immunized animals survived longer, with about 25% of the challenged group ridding themselves completely of the cryptococci. Protection could be demonstrated by cultural analyses, but all animals, whether control or immunized, allowed considerable multiplication of the inoculum during the first 4 weeks after intravenous challenge. It would appear, therefore, t...Continue Reading

Citations

Jan 1, 1987·Critical Reviews in Microbiology·E Segal
Feb 16, 2007·Australian Veterinary Journal·Z M LenardG D Lester
May 1, 1986·Mycopathologia·D T MasihC M Riera
May 1, 1991·Infection and Immunity·C A Salkowski, E Balish
Jun 1, 1983·Infection and Immunity·J E DomerJ W Murphy

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