Apr 18, 2000

Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae

Infection and Immunity
A David OgunniyiJames C Paton

Abstract

The vaccine potential of a combination of three pneumococcal virulence proteins was evaluated in an active-immunization-intraperitoneal-challenge model in BALB/c mice, using very high challenge doses of Streptococcus pneumoniae. The proteins evaluated were a genetic toxoid derivative of pneumolysin (PdB), pneumococcal surface protein A (PspA), and a 37-kDa metal-binding lipoprotein referred to as PsaA. Mice immunized with individual proteins or combinations thereof were challenged with high doses of virulent type 2 or type 4 pneumococci. The median survival times for mice immunized with combinations of proteins, particularly PdB and PspA, were significantly longer than those for mice immunized with any of the antigens alone. A similar effect was seen in a passive protection model. Thus, combinations of pneumococcal proteins may provide the best non-serotype-dependent protection against S. pneumoniae.

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  • Citations130

Citations

Mentioned in this Paper

Toxoids
Mycoplasma pneumoniae
Bacterial Proteins
Pathogenicity
Mice, Inbred BALB C
Chimeric Proteins, Recombinant
Pneumococcal surface protein A
Vaccination
Antigens, Bacterial
Immunization Domain

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