PMID: 5917547Aug 26, 1966

Immunization of normal mouse spleen cell suspensions in vitro

R I Mishell, R W Dutton


Dissociated cells from the spleens of unimmunized mice were cultured with and without various mammalian erythrocytes. Spleen cell suspensions cultured with heterologous red cells developed levels of hemolytic plaque-forming cells only one log(2) less than those seen in vivo. The reaction is specific for the in vitro immunizing erythrocytes. Antibody was demonstrated in the culture fluids.


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