PMID: 9445052Jan 28, 1998Paper

Immunization of pigs with a particle-mediated DNA vaccine to influenza A virus protects against challenge with homologous virus

Journal of Virology
M D MacklinW F Swain

Abstract

Particle-mediated delivery of a DNA expression vector encoding the hemagglutinin (HA) of an H1N1 influenza virus (A/Swine/Indiana/1726/88) to porcine epidermis elicits a humoral immune response and accelerates the clearance of virus in pigs following a homotypic challenge. Mucosal administration of the HA expression plasmid elicits an immune response that is qualitatively different than that elicited by the epidermal vaccination in terms of inhibition of the initial virus infection. In contrast, delivery of a plasmid encoding an influenza virus nucleoprotein from A/PR/8/34 (H1N1) to the epidermis elicits a strong humoral response but no detectable protection in terms of nasal virus shed. The efficacy of the HA DNA vaccine was compared with that of a commercially available inactivated whole-virus vaccine as well as with the level of immunity afforded by previous infection. The HA DNA and inactivated viral vaccines elicited similar protection in that initial infection was not prevented, but subsequent amplification of the infection is limited, resulting in early clearance of the virus. Convalescent animals which recovered from exposure to virulent swine influenza virus were completely resistant to infection when challenged. The p...Continue Reading

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May 14, 2010·Animal Health Research Reviews·Wenjun Ma, Jürgen A Richt
Jan 16, 2013·Expert Opinion on Drug Delivery·Sachiko HirobeShinsaku Nakagawa
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