Abstract
The Centers for Disease Control and Prevention recommend tetanus-diphteria-acellular pertussis (Tdap) immunization during pregnancy, preferably at 27-36 weeks gestation. First, to assess the relative avidity index (RAI) of umbilical cord immunoglobulin G (IgG) to pertussis toxin (PT) for newborns of women immunized with Tdap during late pregnancy as compared to unimmunized women. Second, to assess whether there is a preferential period of gestational Tdap immunization that provides the highest RAI of umbilical cord IgG to PT. RAI of IgG to PT was assessed via an adapted ELISA using NH4SCN as a dissociating agent. We found that newborns of women immunized with Tdap during late pregnancy (n=52) had higher mean RAI of umbilical cord IgG to PT than those of unimmunized women (n=8), 73.77%±12.08 (95% CI, 70.41-77.13) vs. 50.23%±21.32 (95% CI, 32.41-68.06), p<0.001. Further, the RAI of umbilical cord IgG to PT was significantly higher in newborns of women immunized at 27-30(+6) weeks gestation (n=20) when compared with newborns of women immunized at 31-36 weeks (n=22) and >36 weeks (n=7), 79.53%±5.61 (95% CI, 76.91-82.16) vs. 71.56%±12.58 (95% CI, 65.98-77.14) vs. 63.93%±17.98 (95% CI, 47.31-80.56), p<0.03. Gestational Tdap immunizat...Continue Reading
References
Jun 1, 1976·The Journal of Experimental Medicine·S I Morse, J H Morse
Mar 18, 1992·JAMA : the Journal of the American Medical Association·Y Schlesinger, D M Granoff
Dec 20, 1991·Cell·C BerekM Apel
Sep 29, 1995·Annals of the New York Academy of Sciences·U KleinK Rajewsky
Apr 5, 1996·Science·R Ahmed, D Gray
Apr 16, 1998·The Journal of Infectious Diseases·D GoldblattE Miller
Jun 2, 1998·The Journal of Infectious Diseases·M AnttilaH Käyhty
Mar 23, 2001·The Journal of Infectious Diseases·O LiesenfeldJ S Remington
Nov 13, 2004·Clinical and Diagnostic Laboratory Immunology·Andrew L BaughmanFreyja Lynn
Jul 19, 2005·Journal of Virological Methods·J Hofmann, U G Liebert
Jun 1, 2007·The Lancet Infectious Diseases·Frits R Mooi, Sabine C de Greeff
Jun 8, 2007·Journal of Comparative Pathology·J A Englund
Aug 19, 2007·Clinical and Vaccine Immunology : CVI·Philippe A DenoëlJan T Poolman
Sep 26, 2007·Immunity·Thomas Dörner, Andreas Radbruch
Jun 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher D PaddockSherif R Zaki
Mar 10, 2010·Future Microbiology·Nicholas H Carbonetti
Jul 21, 2010·Nature Immunology·Christopher C GoodnowRobert Brink
Jan 6, 2011·FEMS Microbiology Reviews·Daan de GouwFrits R Mooi
Jul 24, 2012·The Journal of Pediatrics·Kathleen WinterGilberto Chavez
Aug 17, 2012·The New England Journal of Medicine·James D Cherry
Sep 18, 2012·Vaccine·Alex-Mikael BarkoffQiushui He
Oct 2, 2012·Journal of Immunological Methods·G AlmanzarM Prelog
Nov 13, 2012·Vaccine·M PrelogJ Liese
Mar 28, 2013·BMC Infectious Diseases·Elena ChiappiniMaurizio de Martino
Mar 13, 2014·Nature Reviews. Microbiology·Jeffrey A MelvinPeggy A Cotter
Aug 26, 2014·Vaccine·Bahaa Abu RayaEllen Bamberger
Sep 1, 2014·Vaccine·Bahaa Abu RayaEllen Bamberger
Citations
Nov 13, 2015·Expert Review of Vaccines·Anita H J van den Biggelaar, Jan T Poolman
Feb 10, 2016·Human Vaccines & Immunotherapeutics·H MarshallK Edwards
Jun 28, 2015·Vaccine·Kirsten MaertensElke Leuridan
Jun 14, 2015·Vaccine·Bahaa Abu RayaAharon Kessel
Apr 14, 2016·Expert Review of Vaccines·Varun K Phadke, Saad B Omer
Apr 20, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christiane S EberhardtClaire-Anne Siegrist
Dec 9, 2016·Human Vaccines & Immunotherapeutics·Giovanni GabuttiPaolo Bonanni
Mar 10, 2017·Virulence·Raïssa Nadège CaboréKris Huygen
Apr 1, 2017·Current Opinion in Infectious Diseases·Anna Calvert, Christine E Jones
Apr 30, 2017·American Journal of Epidemiology·Patricia Therese CampbellNicholas Geard
Apr 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen Winter, Kathleen Harriman
May 2, 2018·Expert Review of Vaccines·Paul LoubetOdile Launay
Sep 18, 2018·Journal of Medical Microbiology·Helen CampbellGayatri Amirthalingam
Sep 20, 2019·Infectious Diseases and Therapy·Charlotte SwitzerDenis Macina
Apr 26, 2017·Virulence·Thomas RiceBeth Holder
May 10, 2019·Frontiers in Immunology·Stephanie N LangelLinda J Saif
Nov 5, 2019·Frontiers in Immunology·Bahaa Abu-RayaManish Sadarangani
Jul 17, 2020·Frontiers in Immunology·Bahaa Abu-RayaSusanna Esposito
Mar 19, 2019·Journal of Immunology Research·Carolina Argondizo-CorreiaCyro Alves de Brito
Aug 28, 2020·Frontiers in Microbiology·Anja Saso, Beate Kampmann
Apr 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bahaa Abu Raya, Michelle Giles
Jan 3, 2021·NeoReviews·Bahaa Abu-Raya, Kirsten Maertens
Sep 17, 2017·Vaccine·Zeina G KhodrAva Marie S Conlin
Mar 4, 2021·The Pediatric Infectious Disease Journal·Katrina MottSonia Hernández-Díaz
Aug 19, 2021·The Journal of Infection·Pere GodoyÀngela Domínguez
Aug 27, 2021·Toxins·Alex-Mikael BarkoffQiushui He
Nov 5, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Federica BrosioGiovanni Gabutti