Immunization of pregnant women against pertussis: the effect of timing on antibody avidity

Vaccine
Bahaa Abu RayaAharon Kessel

Abstract

The Centers for Disease Control and Prevention recommend tetanus-diphteria-acellular pertussis (Tdap) immunization during pregnancy, preferably at 27-36 weeks gestation. First, to assess the relative avidity index (RAI) of umbilical cord immunoglobulin G (IgG) to pertussis toxin (PT) for newborns of women immunized with Tdap during late pregnancy as compared to unimmunized women. Second, to assess whether there is a preferential period of gestational Tdap immunization that provides the highest RAI of umbilical cord IgG to PT. RAI of IgG to PT was assessed via an adapted ELISA using NH4SCN as a dissociating agent. We found that newborns of women immunized with Tdap during late pregnancy (n=52) had higher mean RAI of umbilical cord IgG to PT than those of unimmunized women (n=8), 73.77%±12.08 (95% CI, 70.41-77.13) vs. 50.23%±21.32 (95% CI, 32.41-68.06), p<0.001. Further, the RAI of umbilical cord IgG to PT was significantly higher in newborns of women immunized at 27-30(+6) weeks gestation (n=20) when compared with newborns of women immunized at 31-36 weeks (n=22) and >36 weeks (n=7), 79.53%±5.61 (95% CI, 76.91-82.16) vs. 71.56%±12.58 (95% CI, 65.98-77.14) vs. 63.93%±17.98 (95% CI, 47.31-80.56), p<0.03. Gestational Tdap immunizat...Continue Reading

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Citations

Feb 10, 2016·Human Vaccines & Immunotherapeutics·H MarshallK Edwards
Jun 28, 2015·Vaccine·Kirsten MaertensElke Leuridan
Apr 14, 2016·Expert Review of Vaccines·Varun K Phadke, Saad B Omer
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