PMID: 9653081Jul 7, 1998Paper

Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition

The Journal of Experimental Medicine
C Putterman, B Diamond

Abstract

Anti-double-stranded DNA (dsDNA) antibodies are the serologic abnormality characteristically associated with systemic lupus erythematosus (SLE) and may play an important role in disease pathogenesis. Although the anti-dsDNA antibodies present in SLE are indicative of an antigen-driven response, the antigen has not been conclusively identified. By screening a phage peptide display library, we demonstrated previously that the decapeptide DWEYSVWLSN is specifically bound by the pathogenic murine IgG2b anti-dsDNA antibody R4A. To investigate the possibility that a protein antigen might trigger lupus-like autoimmunity, we immunized BALB/c mice with DWEYSVWLSN in adjuvant. Mice developed significant titers of IgG anti-dsDNA antibodies 2-3 wk after the initial immunization. Immunized mice also developed antibodies against some other lupus autoantigens, and immunoglobulin deposition was present in renal glomeruli at 49 d. Although an immune response to peptide and dsDNA was evident in BALB/c mice, there was little response in other inbred strains. This study demonstrates that lupus-like anti-dsDNA reactivity can be generated in nonautoimmune mice by immunization with a peptide antigen. Peptide-induced autoimmunity may prove useful in u...Continue Reading

References

Jul 1, 1992·Trends in Biochemical Sciences·J K Scott
Aug 1, 1992·Immunological Reviews·T N MarionR J Hill
Jan 1, 1992·Annual Review of Immunology·B DiamondM D Scharff
Feb 1, 1991·The Journal of Experimental Medicine·R ShefnerB Diamond
Mar 1, 1991·The Journal of Clinical Investigation·A GrayzelB Diamond
Feb 1, 1990·Arthritis and Rheumatism·D S PisetskyG S Gilkeson
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S MendlovicE Mozes
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J P Tam
Oct 1, 1984·Molecular Immunology·C DesaymardM D Scharff
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A WesterinkT Kieber-Emmons
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·F TopferJ McCluskey
Mar 1, 1995·The Journal of Clinical Investigation·G S GilkesonD S Pisetsky
Jan 1, 1994·Annual Review of Immunology·M Z Radic, M Weigert
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·S K RayB Diamond
Sep 13, 1996·Journal of Immunological Methods·J P Tam
Jan 1, 1997·Methods : a Companion to Methods in Enzymology·O P RekvigT Traavik
Jan 15, 1997·Annals of Internal Medicine·D S Pisetsky
Jan 27, 1997·Archives of Internal Medicine·D A McCarronF X Pi-Sunyer
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·B GaynorB Diamond

❮ Previous
Next ❯

Citations

Oct 23, 2001·Arthritis and Rheumatism·G RiemekastenF Hiepe
Jan 5, 2002·Arthritis and Rheumatism·T Dörner, P E Lipsky
Jan 19, 2006·Journal of Clinical Immunology·Dirk LangnickelGabriela Riemekasten
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·John G RoutsiasHaralampos M Moutsopoulos
Dec 31, 2002·Journal of Immunological Methods·Jeffrey NewmanBetty Diamond
Jun 20, 2002·Journal of Biotechnology·Kristen Sadler, James P Tam
Aug 19, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bisram DeocharanChaim Putterman
Aug 19, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ram Raj Singh
May 14, 2011·The Journal of Biological Chemistry·Sanjeev KumarDavid A Isenberg
Sep 16, 2009·The Journal of Experimental Medicine·Derrick J ToddLaurie H Glimcher
May 9, 2012·The Journal of Experimental Medicine·Li WangBetty Diamond
Oct 19, 2012·Human Gene Therapy Methods·Vera GeshevaAndrey Tchorbanov
Sep 16, 2000·Current Opinion in Rheumatology·R R Singh
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Jul 19, 2008·The Journal of Clinical Investigation·Ying-Hua Wang, Betty Diamond
Jan 18, 2012·Biology Direct·Neil S GreenspanSteven N Emancipator
Oct 13, 2011·Arthritis Research & Therapy·Ao-Ho HsiehShih-Lien Wang
Dec 21, 2006·PLoS Medicine·Bart J EmmerMark A van Buchem
May 3, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yasuhiko Hirabayashi
Dec 14, 2011·Clinical & Developmental Immunology·Guillaume SeretPierre Youinou
Jan 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey S RiceBetty Diamond
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Patricio T HuertaBetty Diamond
Jun 28, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Rahul D PawarChaim Putterman
Mar 23, 2013·Annual Review of Immunology·B DiamondB T Volpe
Apr 26, 2014·Seminars in Immunopathology·Ole Petter Rekvig, Johan Van der Vlag
Oct 9, 2003·Current Rheumatology Reports·Lisa G Criscione, David S Pisetsky
Oct 21, 2015·Clinical and Experimental Immunology·Y XiaC Putterman
Apr 5, 2011·Seminars in Arthritis and Rheumatism·Michelle PetriKathryn A Carson
Jul 6, 2010·Autoimmunity Reviews·Kalina A NikolovaTchavdar L Vassilev
Jul 8, 2010·La Revue de médecine interne·J F G Cohen-Solal, B Diamond
Jan 6, 2009·Journal of Neuroimmunology·Hua-Xin GaoChaim Putterman
Aug 21, 2008·Journal of Immunological Methods·Jie ZhangBetty Diamond
Feb 22, 2005·Immunology·Sanjeev KumarDavid A Isenberg
May 3, 2003·Annals of the New York Academy of Sciences·Kenneth M KaufmanJudith A James
Jun 26, 2008·Arthritis and Rheumatism·Casandra C van BavelJo H Berden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
B GaynorB Diamond
Proceedings of the National Academy of Sciences of the United States of America
Jeffrey S RiceBetty Diamond
© 2022 Meta ULC. All rights reserved