PMID: 9420626Jan 8, 1998Paper

Immunization with alum-collagen II complex suppresses the development of collagen-induced arthritis in rats by deviating the immune response

Scandinavian Journal of Immunology
L MattssonP Larsson

Abstract

Collagen-induced arthritis (CIA) is an experimental rat model sharing a number of features with human rheumatoid arthritis (RA). The model is associated with a proinflammatory (TH1) type of immune response and treatments with cytokines associated with TH2 immune responses are beneficial. Since agents with TH1-inducing properties, such as Freund's incomplete adjuvant (FIA), are necessary for disease induction, it is of interest to investigate whether an adjuvant with TH2-inducing properties affects CIA in a different way than does FIA. The authors studied arthritis development in DA rats after immunization with the TH2 stimulatory adjuvant alum adsorbed to rat collagen type II (CII) or collagen II fragments. Such treatments suppressed disease development both prophylactically and therapeutically. This beneficial effect of alum-CII immunization was associated with an increase in the IgG1 anti-CII antibody response as compared to untreated rats or rats pretreated with alum alone. Treatment with alum without the addition of collagen did not have any clinical effect. In addition, alum-CII treated rats had a significantly higher expression of IL-4 mRNA than untreated rats in the lymph nodes, 7 days after CIA induction. The authors su...Continue Reading

Citations

Feb 10, 2000·Springer Seminars in Immunopathology·L R Wedderburn, P Woo
Mar 21, 2002·Scandinavian Journal of Immunology·L SvelanderJ C Lorentzen
Jun 16, 2004·Clinical and Experimental Immunology·B C HolmA Bucht
Mar 25, 2005·Scandinavian Journal of Immunology·D D T NgocP Larsson
Aug 24, 2004·Scandinavian Journal of Immunology·A MirshafieyP Larsson
Aug 2, 2006·Clinical and Experimental Immunology·E WestmanH Erlandsson Harris
Aug 25, 2004·Journal of Autoimmunity·Karin LundbergHelena Erlandsson Harris
Jan 4, 2007·The American Journal of Pathology·Philip StashenkoAntonio Campos-Neto
Sep 26, 2006·Immunopharmacology and Immunotoxicology·A MirshafieyS Cuzzocrea
Jan 20, 2007·European Journal of Immunology·Robert Bockermann, Rikard Holmdahl
Aug 19, 2000·Endocrine Reviews·W Savino, M Dardenne
Jan 27, 2006·Immunopharmacology and Immunotoxicology·Salvatore CuzzocreaAbbas Mirshafiey
Jan 10, 2012·Homeopathy : the Journal of the Faculty of Homeopathy·César SatoLeoni Villano Bonamin
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K G TournoyR A Pauwels
Dec 21, 2000·Clinical and Experimental Immunology·L MattssonR A Harris

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