Immunization with an HIV-1 immunogen induces CD4+ and CD8+ HIV-1-specific polyfunctional responses in patients with chronic HIV-1 infection receiving antiretroviral therapy

Vaccine
L ValorSTIR-2102 Team

Abstract

Development of polyfunctional T lymphocyte responses is critical in the immunological response against HIV-1. Fifty-four HIV-1 infected patients receiving antiretroviral treatment (ART) and immunization with an HIV-1 immunogen or placebo, periodically every 3 months throughout a period of 36 months, were evaluated for the purposes of analysing the development of HIV-1-specific CD4+ and CD8+ responses. A significant increase of proliferating and IFN-gamma producing CD8+ HIV-1-specific T cells, of HIV-1-specific precursor frequencies for CD8+ and for CD4+ T cells and of Gag/pol-specific memory CTL precursors (CTLp) was observed in the immunogen group in comparison to placebo. IL-2 intracellular expression and IFN-gamma and TNF-alpha co-expression in HIV-1-specific CD8+ T cells were also substantially increased in the immunized group. A negative correlation between viral load and CD3+CD4+CFSElow HIV-1-specific lymphoproliferative response and frequency of Gag/pol-specific CTLp was solely observed in the HIV-1 immunogen group. Long-term immunization in patients receiving ART helps to develop HIV-1-specific polyfunctional T cell responses.

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Citations

Mar 26, 2011·Expert Review of Vaccines·Meredith SlotaMary L Disis
Nov 28, 2012·Immunology Letters·Darien García-DíazEnrique Iglesias
Jan 14, 2012·International Immunopharmacology·Enrique IglesiasDarien García
Apr 20, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carmen Rodríguez-SáinzEduardo Fernández-Cruz
Apr 11, 2013·Human Vaccines & Immunotherapeutics·Enrique Iglesias
Jun 9, 2016·Expert Opinion on Biological Therapy·Gina M Graziani, Jonathan B Angel

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