Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells

European Journal of Immunology
U M Abdel-MotalM Jondal

Abstract

Cytotoxic T cells (CTL) recognize target proteins as short peptides presented by major histocompatibility complex (MHC) class I restriction elements. However, there is also evidence for peptide-independent T cell receptor (TCR) recognition of target proteins and non-protein structures. How such T cell responses are generated is presently unclear. We generated carbohydrate (CHO)-specific, MHC-unrestricted CTL responses by coupling di- and trisaccharides to Kb- or Db-binding peptides for direct immunization in mice. Four peptides and three CHO have been analyzed with the CHO either in terminal or central position on the carrier peptide. With two of these glycopeptides, with galabiose (Gal alpha 1-4Gal; Gal2) bound to a homocysteine (via an ethylene spacer arm) in position 4 or 6 in a vesicular stomatitis virus nucleoprotein-derived peptide (RGYVYQGL binding to Kb), CTL were generated which preferentially killed target cells treated with glycopeptide compared to those treated with the core peptide. Polyclonal CTL were also found to kill target cells expressing the same Gal2 epitope in a glycolipid. By fractionation of CTL, preliminary data indicate that glycopeptide-specific Kb-restricted CTL and unrestricted CHO-specific CTL belo...Continue Reading

References

Aug 30, 1992·Journal of Immunological Methods·X ZhouM Jondal
May 1, 1990·The Journal of Experimental Medicine·P AicheleM Schulz
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W M KastC J Melief
Aug 2, 1990·Nature·H G LjunggrenK Kärre
Jul 1, 1990·Hematological Oncology·A AielloG Della Porta
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J WielsT Tursz
May 1, 1994·International Archives of Allergy and Immunology·S Martin, H U Weltzien
Jan 1, 1994·The Journal of Experimental Medicine·E P RockY H Chien
Jan 1, 1993·Annual Review of Immunology·H G RammenseeO Rötzschke
Jan 1, 1993·Annual Review of Immunology·R N Germain, D H Margulies
Jan 1, 1993·Annual Review of Immunology·W HaasS Tonegawa

❮ Previous
Next ❯

Citations

Jun 5, 2003·International Journal for Parasitology·Gina Cunto-AmestyThomas Kieber-Emmons
Jul 17, 1998·Current Opinion in Chemical Biology·M Meldal, P M St Hilaire
Mar 3, 2004·The Journal of Experimental Medicine·Yanfei XuAlessandra Franco
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexander H LucasChristopher E Taylor
Aug 3, 2012·Immunotherapy·Teresa Freire, Eduardo Osinaga
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vasso ApostolopoulosIan F C McKenzie
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ole WerdelinTeis Jensen
Feb 20, 2016·ACS Chemical Biology·Danyang FengFengshan Wang
Jun 16, 2001·The Journal of Investigative Dermatology·S J SeoC L Reardon
Aug 8, 2008·Seminars in Immunology·Andrea SchietingerHans Schreiber
Jul 22, 2014·Immunology·Tal GefenJacob Pitcovski
Aug 19, 2015·Journal of the American Chemical Society·Fabio MarinoAlbert J R Heck
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Anastas PashovThomas Kieber-Emmons
Jun 13, 2013·Seminars in Immunology·Fikri Y AvciDennis L Kasper
May 23, 2012·Cell Host & Microbe·René M Roy, Bruce S Klein
Feb 3, 2015·Frontiers in Immunology·Gennaro De LiberoLucia Mori
Jul 30, 2014·Frontiers in Immunology·Thomas Kieber-EmmonsRamachandran Murali
Feb 20, 2002·Biologicals : Journal of the International Association of Biological Standardization·B Monzavi-KarbassiT Kieber-Emmons
May 29, 2016·Glycobiology·Lina SunFikri Y Avci
Jul 23, 1998·Critical Reviews in Biochemistry and Molecular Biology·P Van den SteenG Opdenakker
Oct 1, 1996·Immunity·M JondalJ Reimann
Oct 25, 2001·International Immunology·B Monzavi-KarbassiT Kieber-Emmons
Jan 1, 2011·Cancers·Klervi Even-DesrumeauxPatrick Chames
Jan 1, 2013·Vaccines·Behjatolah Monzavi-KarbassiThomas Kieber-Emmons
Jul 15, 1999·Nature Biotechnology·T Kieber-EmmonsZ Steplewski
Jun 9, 2004·Chembiochem : a European Journal of Chemical Biology·Fredrik K WallnerMikael Elofsson
Aug 11, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Serge MoffettRené Roy
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C T CadyW K Born
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrzej WierzbickiDanuta Kozbor
Jul 28, 2020·Cellular & Molecular Immunology·Malte Deseke, Immo Prinz
Apr 3, 2012·Journal of Carbohydrate Chemistry·Zhaojun Yin, Xuefei Huang
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S HondaS G Nathenson
Aug 30, 2003·Organic & Biomolecular Chemistry·Mickael MogemarkJan Kihlberg
Aug 26, 2016·Glycobiology·Ajit Varki
Mar 18, 2004·Cancer Research·Behjatolah Monzavi-KarbassiThomas Kieber-Emmons
Feb 9, 2021·Frontiers in Immunology·Alex OlveraChristian Brander
Mar 28, 2001·Science·P M RuddR A Dwek

❮ Previous
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