Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis

Emerging Infectious Diseases
Robert B TeshShu-Yuan Xiao

Abstract

Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized with each of the heterologous flaviviruses; approximately 30 days later, the animals were injected intraperitoneally with a virulent New York strain of WNV. Subsequent levels of viremia, antibody response, and deaths were compared with those in nonimmune (control) hamsters. Immunity to JEV and SLEV was protective against clinical encephalitis and death after challenge with WNV. The antibody response in the sequentially infected hamsters also illustrates the difficulty in making a serologic diagnosis of WNV infection in animals (or humans) with preexisting Flavivirus immunity.

References

Sep 16, 1998·Lancet·T F TsaiN I Nedelcu
Oct 8, 1999·Emerging Infectious Diseases·Z Hubálek, J Halouzka
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D S AsnisB A Sampson
Mar 27, 2001·Emerging Infectious Diseases·A E PlatonovV I Pokrovskii
Aug 23, 2001·Trends in Molecular Medicine·J ArroyoT P Monath
Mar 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·W M HAMMON, G E SATHER
Jan 1, 1957·Transactions of the New York Academy of Sciences·J CASALS

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Citations

Aug 24, 2004·Antiviral Research·Nathalie CharlierJohan Neyts
Aug 30, 2005·Bulletin of Mathematical Biology·Gustavo Cruz-PachecoCristobal Vargas
Mar 6, 2004·Comparative Immunology, Microbiology and Infectious Diseases·Dana M NelsonN James Maclachlan
Jun 5, 2003·International Journal for Parasitology·Konstantin V PugachevThomas P Monath
Mar 18, 2009·Epidemiology and Infection·J Alonso-PadillaJ C Saiz
May 13, 2008·Expert Reviews in Molecular Medicine·Theodore C Pierson, Michael S Diamond
Mar 20, 2008·Animal Health Research Reviews·Bradley J Blitvich
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher D PaddockSherif R Zaki
Jun 6, 2009·Vector Borne and Zoonotic Diseases·María de Lourdes Garza RodríguezAna Maria Rivas-Estilla
Sep 22, 2010·Vector Borne and Zoonotic Diseases·Marietjie Venter, Robert Swanepoel
Jan 4, 2012·Transboundary and Emerging Diseases·I García-BocanegraA Arenas
Nov 27, 2004·Journal of Virology·Wayne D Crill, Gwong-Jen J Chang
Jan 18, 2006·Annual Review of Medicine·Edward B Hayes, Duane J Gubler
Dec 15, 2010·Annals of Tropical Medicine and Parasitology·A F van den HurkC C Jansen
Dec 10, 2009·The Journal of Veterinary Medical Science·Jiro HirotaShinya Shimiz
May 13, 2009·Journal of the American Mosquito Control Association·Joshua SmithRoberto Barrera
Aug 2, 2003·Emerging Infectious Diseases·Mario Stefano PeragalloUNKNOWN East Timor Dengue Study Group
Oct 2, 2003·Emerging Infectious Diseases·Michael J TurellCarl J Mitchell
Jan 15, 2004·Emerging Infectious Diseases·José G Estrada-FrancoScott C Weaver
Jan 25, 2005·Emerging Infectious Diseases·Aaron C BraultNicholas Komar
Oct 19, 2005·Emerging Infectious Diseases·Darwin Elizondo-QuirogaRobert B Tesh
Sep 13, 2013·International Journal of Environmental Research and Public Health·Arun V Iyer, Konstantin G Kousoulas
Oct 19, 2013·International Journal of Environmental Research and Public Health·Brian R MannAlan D T Barrett
Nov 15, 2013·International Journal of Environmental Research and Public Health·Cécile BeckSylvie Lecollinet
Dec 20, 2013·International Journal of Environmental Research and Public Health·Hiroaki KariwaIkuo Takashima
Mar 3, 2011·The American Journal of Tropical Medicine and Hygiene·Ryo MurataIkuo Takashima
May 5, 2011·The American Journal of Tropical Medicine and Hygiene·Angela Bosco-LauthRichard Bowen
Feb 10, 2009·Journal of Medical Entomology·William K ReisenRob Quiring
Nov 6, 2015·Journal of Wildlife Diseases·Nohemi Cigarroa-ToledoCarlos Machain-Williams
Jul 29, 2008·Neurologic Clinics·Larry E DavisKenneth L Tyler

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