PMID: 9555976Apr 29, 1998Paper

Immunization with HSV-1 antigen rapidly protects against HSV-1-induced encephalitis and is IFN-gamma independent

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
W P HalfordD J Carr

Abstract

Herpes simplex virus type 1 (HSV-1) infection of mice frequently culminates in fatal encephalitis. Intraperitoneal administration of heat-inactivated HSV-1 0-5 days before infection (active immunization) protected mice from encephalitis. In addition, active immunization 2-5 days before ocular infection with HSV-1 reduced the frequency of establishment of latent HSV-1 infection in the trigeminal ganglion (TG). However, intraperitoneal administration of heat-inactivated HSV-1 did not induce interferon (IFN) production in the peritoneum or serum, as determined by bioassay and ELISA. Intraperitoneal administration of heat-attenuated HSV-1 elicited IFN-gamma but not type I IFN production in the peritoneum. The production of IFN-gamma correlated with the infiltration of CD4 and CD8 cells in the peritoneum as determined by RT-PCR. In addition, there was a significant increase in interleukin (IL)-12 p40, IL-12p35, IL-6, IL-10, and IFN-gamma mRNA in peritoneal cells, as determined by RT-PCR following immunization with heat-attenuated HSV-1, which was not observed using heat-inactivated HSV-1. The results suggest that resistance to HSV-1 is induced rapidly following immunization with viral antigen but that protection against encephalitis...Continue Reading

References

Sep 1, 1979·The Journal of General Virology·S NagafuchiT Taniguchi
Jan 1, 1992·Archives of Virology·M ErturkR Jennings
Jul 1, 1991·The Journal of General Virology·R L HendricksJ C Glorioso
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Aug 27, 1971·Science·J G Stevens, M L Cook
Jul 1, 1974·The Journal of Infectious Diseases·F B KnottsJ G Stevens
Apr 1, 1981·Infection and Immunity·P S MorahanB K Murray
Nov 5, 1997·Virology·W P HalfordD J Carr

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