PMID: 9632583Jun 25, 1998Paper

Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P. carinii pneumonia

Infection and Immunity
F GigliottiA G Harmsen

Abstract

Immunization with whole Pneumocystis carinii has been shown to protect mice from the development of P. carinii pneumonia (PCP) when they are subsequently immunosuppressed and challenged with viable organisms. To determine whether these results could be duplicated by using a subunit vaccine, we examined the immunogenicity and efficacy of an immunization strategy based on P. carinii gpA. This antigen was chosen for study because passive immunoprophylaxis, based on gpA, has been shown to be partially protective in various animal models of infection. Immunization with gpA produced an anti-gpA specific antibody response comparable to that resulting from immunization with whole organisms. However, in contrast to immunization with whole P. carinii, which was protective, immunization with gpA did not protect T-cell-depleted mice from the development of PCP. These studies suggest that other antigens in addition to gpA need to be evaluated for their role in protective immunity against P. carinii.

References

Dec 26, 1991·The New England Journal of Medicine·M C SteinhoffR E Chaisson
Jan 1, 1989·The Journal of protozoology·D C Graves
Oct 22, 1987·The New England Journal of Medicine·D R SnydmanA S Levey
Jan 1, 1986·Infection and Immunity·D C GravesM A Worley
Jul 1, 1995·Infection and Immunity·A G HarmsenF Gigliotti
Nov 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A Zaia

❮ Previous
Next ❯

Citations

Mar 23, 2006·Infection and Immunity·Jesse WellsFrancis Gigliotti
Jan 2, 2007·Journal of Immunotherapy·Hiroyasu KobayashiRonald G Crystal
Nov 21, 2001·The Journal of Clinical Investigation·M ZhengJ K Kolls
Feb 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Derrick R SamuelsonDavid A Welsh
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A Fishman
Nov 19, 2008·The Journal of Infectious Diseases·Heather M KlingKaren A Norris
Feb 13, 2001·Infection and Immunity·J R Stringer, S P Keely
Jun 6, 2018·The Journal of Infectious Diseases·Monica SassiJoseph A Kovacs
Jan 23, 1999·Infection and Immunity·J M PascaleG L McLaughlin
Mar 7, 2021·Pathogens·Aaron D GingerichJarrod J Mousa
Mar 6, 1999·Clinical and Diagnostic Laboratory Immunology·P D Walzer
Oct 31, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jang-Jih Lu, Chao-Hung Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.