PMID: 9537026Jan 1, 1980Paper

Immunization with the light chain and the VL domain of the isologous myeloma protein 315 inhibits growth of mouse plasmacytoma MOPC315

Scandinavian Journal of Immunology
T JørgensenK Hannestad

Abstract

Prior immunization of BALB/c mice with free light chains from myeloma protein 315 (L315) and its variable domain (VL315) inhibited the growth of subcutaneously injected MOPC315 tumour cells. The growth suppression observed after immunization with L315 was equivalent to that which resulted from immunization with the complete M315. VL315 and non-polymerized L315 did not elicit specific antibodies. Polymerized L315 induced both suppression of MOPC315 growth and antibodies specific for free L315; however, these antibodies did not react with the complete M315, nor were they absorbed by MOPC315 tumour cells. The data indicate that the suppression of tumour growth was mediated by specifically sensitized cells acting in the absence of antibodies against M315 or L315. Immunization with the variable domain of the heavy chain from M315 (VH315) had no effect on the growth of MOPC315. The M315 fragments and subunits that induced growth suppression were thus identical with those capable of inducing T helper cells in BALB/c mice.

References

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Citations

Aug 5, 2003·Current Oncology Reports·Mohammed M Dar, Larry W Kwak
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N SakatoT Azuma
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·G F LauritzsenB Bogen
Jan 1, 1993·Scandinavian Journal of Immunology·G F LauritzsenB Bogen
Apr 23, 2004·Leukemia & Lymphoma·Ross BrownDoug Joshua
Jun 4, 2004·Expert Opinion on Biological Therapy·Marta Coscia, Larry W Kwak
Jan 1, 1997·Cancer Investigation·C B Kobrin, L W Kwak
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Jun 22, 2005·Bone Marrow Transplantation·S S NeelapuL W Kwak
Jan 1, 1989·International Reviews of Immunology·A J George, F K Stevenson
Nov 1, 1995·European Journal of Immunology·B BogenG F Lauritzsen
Feb 28, 2007·Yonsei Medical Journal·Seung-Tae LeeLarry W Kwak
Apr 25, 2008·Current Protocols in Immunology·Arya Biragyn, Larry W Kwak
Mar 17, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Cristina Gasparetto
Oct 1, 1981·Experimental Cell Research·G Kaplan, R Olstad
May 14, 1993·Science·A Lanzavecchia

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