Immuno-electron-microscopic localization of types III pN-collagen and IV collagen, laminin and tenascin in developing and adult human spleen

Cell and Tissue Research
A LiakkaH Autio-Harmainen

Abstract

The distribution of the extracellular matrix proteins types III pN-collagen and IV collagen, laminin and tenascin was investigated in fetal, infant, and adult human spleens by using immuno-electron microscopy. The presence of type III pN-collagen was assessed by using an antibody against the aminoterminal propeptide of type III procollagen. All the proteins other than type III pN-collagen were found in reticular fibers throughout development. In the white pulp of the fetus aged 16 gestational weeks, only an occasional type III pN-collagen-containing fibril was present, although type III pN-collagen was abundant in the reticular fibers of the red pulp. Conversely, in adults, most of the reticular fibers of the white pulp, but not of the red pulp, were immunoreactive for type III pN-collagen. Ring fibers, the basement membranes of venous sinuses, were well developed in both infant and adult spleens. The first signs of their formation could be seen as a discontinuous basement membrane, which was immunoreactive for type IV collagen, laminin, and tenascin in the fetus aged 20 gestational weeks. Intracytoplasmic immunoreactivity for all the proteins studied was visible in the mesenchymal cells of the fetus aged 16 gestational weeks a...Continue Reading

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Citations

May 5, 1997·The Journal of Cell Biology·R A ClarkT A Springer
Oct 3, 2013·Experimental Hematology·Sarah L EllisSusan K Nilsson
Feb 5, 2008·Seminars in Immunology·Zerina LokmicLydia Sorokin
Jan 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Ruth Chiquet-EhrismannKim S Midwood
May 20, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Gerdy B ten DamToin H van Kuppevelt
Jun 20, 2018·PeerJ·Chatchote ThitaramKorakot Nganvongpanit

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