Immuno-epidemiology of chronic bacterial and helminth co-infections: observations from the field and evidence from the laboratory

International Journal for Parasitology
A K PathakIsabella M Cattadori

Abstract

Co-infections can alter the host immune responses and modify the intensity and dynamics of concurrent parasitic species. The extent of this effect depends on the properties of the system and the mechanisms of host-parasite and parasite-parasite interactions. We examined the immuno-epidemiology of a chronic co-infection to reveal the immune mediated relationships between two parasites colonising independent organs, and the within-host molecular processes influencing the dynamics of infection at the host population level. The respiratory bacterium, Bordetella bronchiseptica, and the gastrointestinal helminth, Graphidium strigosum, were studied in the European rabbit (Oryctolagus cuniculus), using long-term field data and a laboratory experiment. We found that 65% of the rabbit population was co-infected with the two parasites; prevalence and intensity of co-infection increased with rabbit age and exhibited a strong seasonal pattern with the lowest values recorded during host breeding (from April to July) and the highest in the winter months. Laboratory infections showed no significant immune-mediated effects of the helminth on bacterial intensity in the lower respiratory tract but a higher abundance was observed in the nasal cavi...Continue Reading

References

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Jan 1, 2011·Results in Immunology·Ashutosh K PathakIsabella M Cattadori

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Citations

Apr 25, 2014·Integrative and Comparative Biology·Romain Garnier, Andrea L Graham
Mar 20, 2014·The American Naturalist·Charles L NunnVanessa O Ezenwa
May 2, 2014·Journal of Helminthology·K A LambertI M Cattadori
May 30, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Bruna Correa LopesFabiana Quoos Mayer

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