PMID: 2118484Sep 15, 1990Paper

Immuno-isotachophoretic determination of monoclonal immunoglobulin light chains produced by neoplastic B-cells: use in diagnosis, monitoring and detection of residual disease

International Journal of Cancer. Journal International Du Cancer
G I AbelevG V Kruglova

Abstract

We suggest that countercurrent isotachophoresis performed on cellulose acetate membranes (ITP-CAM) should be used for detecting trace amounts of Bence-Jones protein (BJP) in urine of patients with chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL) and related diseases. ITP-CAM allows simultaneous concentration and electrophoretic separation of proteins present in highly diluted solutions, as well as easy immunological detection of separated substances. BJP was found in 24 out of 42 patients with CLL, 33 of 56 with NHL and 3 of 3 with Waldenström macroglobulinemia. Twenty-three patients were followed during the course of chemo- or radiotherapy. In 19 cases the BJP findings correlated well with clinical status. In no case of partial or complete clinical response did BJP completely disappear from the urine.

References

Jan 1, 1986·Acta Haematologica·E Pascali, A Pezzoli
Jul 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·A G NordenF V Flynn
Jan 1, 1986·Scandinavian Journal of Haematology·A Pezzoli, E Pascali
Nov 1, 1984·Analytical Biochemistry·G I Abelev, E R Karamova
May 1, 1980·British Journal of Cancer·J PiersonM Virji

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Citations

Feb 24, 2015·Journal of Gastrointestinal Cancer·Magalí Chahdi BeltrameRodrigo Sánchez Clariá
Apr 15, 1999·Seminars in Cancer Biology·G I Abelev, S Sell
Jun 15, 1993·Analytical Chemistry·W E Katzin

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