PMID: 7539352Feb 1, 1995Paper

Immuno-localization of the calcitriol receptor, calbindin-D28k and the plasma membrane calcium pump in the human eye

Current Eye Research
J A JohnsonR Kumar

Abstract

Using immunohistochemical methods, we detected epitopes of the calcitriol receptor, the ATP-dependent plasma membrane calcium pump and the 28kD vitamin D-dependent calcium-binding protein in sections of the human eye. In retinal photoreceptors, vitamin D receptor, plasma membrane calcium pump and calcium-binding protein epitopes were detected in the outer nuclear layer. Epitopes for the vitamin D receptor and the calcium-binding protein were present in the inner and outer segments of the photoreceptors, where visual transduction occurs. All three proteins were detected in some cells of the ganglion cell layer, the inner nuclear layer, and the retinal pigment epithelium. Epitopes for these proteins also were noted in the ciliary body epithelium. VDR epitopes were seen in lens epithelium. Some immunostaining for VDR, PMCA and calbindin-D28k also was present in the endothelium and in the basal epithelium of the cornea. The presence of these proteins in several tissues of the human eye suggests that the proteins may play a role in the cellular physiology of the eye. Their exact functions in the eye remain undetermined.

References

Mar 1, 1992·The Journal of Nutrition·R H WassermanR Kumar
Jan 1, 1992·Annual Review of Physiology·U B Kaupp, K W Koch
Dec 30, 1992·Biochemical and Biophysical Research Communications·R KumarE Wieben
Jun 1, 1992·Neuron·L Lagnado, D Baylor
Sep 1, 1990·Pflügers Archiv : European journal of physiology·J L BorkeR Kumar
Jun 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S R ShiK L Kalra
Jan 1, 1991·Brain Research. Molecular Brain Research·A K Hall, A W Norman
Jul 1, 1990·Visual Neuroscience·B PasteelsR Pochet
Mar 1, 1985·Current Eye Research·S Iwata
Aug 1, 1989·The American Journal of Physiology·J L BorkeR Kumar
Oct 1, 1989·Current Eye Research·D BorchmanN A Delamere
Jun 1, 1989·Biomedical & Environmental Mass Spectrometry·A TsarbopoulosI Jardine
Jul 1, 1988·The American Journal of Clinical Nutrition·P F JacquesJ A Sadowski
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y S LeeR H Wasserman
Jan 1, 1986·Ophthalmic Research·A VerstappenR Pochet
Jan 1, 1985·Acta Anatomica·D S SchreinerD E Lawson
Aug 31, 1982·Biochemistry·E GrafJ T Penniston
May 1, 1982·The British Journal of Ophthalmology·A J Dark, J Proctor
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Q CaiJ T Penniston
Nov 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S R ShiC R Taylor

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Citations

Jan 23, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Saadettin SelNorbert Nass
Sep 7, 2016·Eye and Vision·Swaminathan SethuArkasubhra Ghosh
Oct 14, 2017·Nutrients·Alfredo Garcia LayanaJohanna M Seddon
Apr 18, 2018·Pharmaceutical Research·Shallu KutlehriaMandip Singh
Apr 16, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Theodore A CraigRajiv Kumar
May 27, 2017·British Journal of Pharmacology·Stephanie L Merrigan, Breandán N Kennedy
Sep 7, 2017·Seminars in Ophthalmology·Muhammed KizilgulErman Cakal
Mar 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S LundgrenP Hellman
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nasim JamaliNader Sheibani
Feb 6, 2020·European Journal of Ophthalmology·Esra VuralAli Rıza Cenk Çelebi
Oct 28, 2016·Current Medical Research and Opinion·Anna Maria ZicariMarzia Duse
Mar 25, 2020·International Ophthalmology·Seyhan DikciTülay Yıldırım
Feb 4, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nurgül ÖrnekÜçler Kısa
Apr 25, 2021·The Ocular Surface·Robert M LavkerC Shad Thaxton
Feb 4, 1998·Archives of Biochemistry and Biophysics·N J KoszewskiR L Horst
Apr 10, 2003·Biochemical and Biophysical Research Communications·Ward LutzRajiv Kumar
Oct 7, 2004·Analytical Biochemistry·Sergei Yu VenyaminovTheodore A Craig
Jun 26, 2021·Curēus·Hatice Daldal, Ayla Gokmen Salici
Feb 14, 2006·Progress in Retinal and Eye Research·Geoffrey B Arden, Paul A Constable
Aug 31, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sedat Arikan, Fatih Kamis
Sep 18, 2021·Journal of Neuroinflammation·Francesca LazzaraClaudio Bucolo
Dec 3, 2009·Progress in Retinal and Eye Research·Daniel T Organisciak, Dana K Vaughan

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