PMID: 7084803Jul 1, 1982Paper

Immunoactive trypsins in duodenal juice from children with gastrointestinal disorders

Gut
S Borulf, T Lindberg

Abstract

Duodenal juice contains two trypsins, one anionic and one cationic at pH 8.6. To investigate their distribution, we studied fasting specimens of duodenal juice from 89 children with different gastrointestinal problems. The two trypsins were separately determined with electroimmunoassay parallel with determinations of total trypsin esterolytic activity and total protein. In 81 children with normal pancreatic function the ratio immunoactivity: esterolytic activity averaged 3.25:1. Anionic trypsin comprised an average 12% of immunoactivity: the average trypsin contribution to the total protein content was 37% for immunoactivity and 12% for esterolytic activity. These ratios were not influenced by age. Fourteen children with coeliac disease had significantly lower mean values for trypsins and total protein'. Eight children with pancreatic insufficiency had discrepant trypsin distribution, anionic trypsin being the dominant residuum in five of the eight.

References

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Citations

Jan 1, 1995·European Journal of Pediatrics·M H TuliniusB Kristiansson
May 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·T LindbergB Lönnerdal
Mar 1, 1983·Acta Oto-laryngologica·B CarlssonK Ohlsson
Jan 1, 1987·Acta paediatrica Scandinavica·S BorulfM Månsson
Jun 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·D W Kissane, S Bloch
Jan 1, 1990·Scandinavian Journal of Psychology·A Dyregrov
Jan 1, 1991·Scandinavian Journal of Psychology·A Dyregrov, S B Matthiesen
Jan 1, 1987·Scandinavian Journal of Psychology·A Dyregrov, S B Matthiesen
Jan 1, 1987·Scandinavian Journal of Psychology·A Dyregrov, S B Matthiesen
Jan 1, 1987·Scandinavian Journal of Psychology·A Dyregrov, S B Matthiesen

Related Concepts

Celiac Disease
Duodenum
Cholera Infantum
Immunoassay Method
Intestinal Secretions
Exocrine Pancreatic Insufficiency
Trypure

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