Immunoadsorption method using immunoglobulin Adsopak in adult cases with ITP resistant to splenectomy and other medical therapies

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Oktay BilgirEsin Kula

Abstract

Despite all medical therapies and splenectomy performed, severe life-threatening thrombocytopenia persists in many adult patients. To evaluate the efficiency of Immunoglobulin Adsopak immunoadsorption method in eliminating circulating immunocomplexes and IgG from plasma in these cases. The method of POCARD Ig-Adsopak Wide Spectrum was applied to four cases with severe thrombocytopenia (< or =20.000/microL) by treating with a daily plasma of 0.25-2 L for 6 days. Platelet counts were recorded at the beginning and during administration of the method. For long-term effects, the cases were called for monthly controls during which platelet counts were measured. Platelet counts of four cases started to increase on average as of the first day. On Day 11, the platelet count reached 50.000/microL. On the following days (Day 17), platelet count was recorded as 90.000/microL. Cases were followed up for a mean of 2 years. At the end of 2 years, mean platelet count of the patients was 210.000 (175.000-265.000) microL. In adult cases who do not respond to surgical and medical therapy, including splenectomy, the results obtained from the therapy using the method of Immunoadsorption with Immunoglobulin Adsopak are promising both in short and lo...Continue Reading

References

Nov 4, 2000·Expert Opinion on Investigational Drugs·N Braun, T Bosch
Mar 29, 2002·The New England Journal of Medicine·Douglas B Cines, Victor S Blanchette
Apr 6, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jan Pták
Mar 30, 2005·American Journal of Hematology·Peter BraendstrupHans C Hasselbalch
Oct 6, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jan Pták

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