PMID: 11899750Mar 20, 2002Paper

Immunoadsorption therapy (therasorb) in patients with severe lupus erythematosus

Acta medica Austriaca
Monika GraningerW B Graninger

Abstract

Therapeutic removal of immune complexes and antibodies by plasmapheresis has been used in patients with systemic lupus erythematosus (SLE) since 1974. Modern methods of selective adsorption of immunoglobulins from the patient plasma (immunoadsorption, IAS) have been developed; they deserve to be investigated as a tool in the management of difficult cases of SLE. We report our experience in an uncontrolled series of five consecutive SLE patients, in whom cytotoxic immunosuppression was contraindicated or not sufficient to control the disease. Ig-Therasorb columns containing polyclonal sheep antihuman immunoglobulin antibodies were used for IAS for periods of 4 to 54 weeks. In order to prevent rebound autoantibody production, low doses of normal human immunoglobulin were substituted. Improvement in clinical and laboratory signs of disease activity was observed in all patients. In two patients the effect of cyclophosphamide therapy for lupus pneumonitis and lupus-associated thrombopenic purpura was consolidated. In three patients suffering from pancytopenia or lupus vasculitis, the use of cytotoxic substances could be avoided for more than a year. IAS seems to be a safe replacement of conventional plasmapheresis in difficult cases...Continue Reading

References

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Citations

Jun 18, 2004·Kidney International·Gürkan SengoelgeGere Sunder-Plassmann
Mar 21, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Christian Pagnoux
Jul 28, 2004·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ioannis GriveasGeorgios Sakellariou
Nov 30, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Shori TakahashiKensuke Harada
May 15, 2003·Shock·Andrea M StahlGary W Mack
Nov 16, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefan WöhrlDetlef Zillikens
Nov 6, 2004·Renal Failure·George VisvardisGeorge Sakellariou

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