Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Llúcia AlòsElias Campo

Abstract

Plasma viral load and T-cell subset determinations in blood are the markers used for monitoring HIV-1 infection. However, key pathogenesis events, viral replication and most immunologic changes occur in the lymphoid tissues. We have studied the tonsillar biopsies of 30 patients in the early stages of the disease, before initiating treatment and after 12 and 36 months of fully effective highly active antiretroviral therapy. We have investigated the HIV RNA by polymerase chain reaction (lymphoid tissue viral load), the immunohistochemical HIV-p24 antigen expression, as well as the lymphoid tissue architecture and lymphoid cell subsets using morphometry. The lymphoid tissue viral load and the immunoexpression of p24, which was found to be mainly associated with follicular dendritic cells, decreased significantly after treatment, but did not disappear in all cases, even after 36 months of treatment. A significant improvement of the lymphoid tissue architecture was also observed after treatment, with recovery of follicular structures. These histological changes correlated with the lymphoid tissue viral load. Moreover, the counts of CD4+ increased whereas CD8+ and cytotoxic lymphocytes (CD8+ granzyme B+) decreased significantly, the ...Continue Reading

References

Jan 1, 1997·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·L GinaldiD Quaglino
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z Q ZhangA T Haase
Feb 18, 1999·The Journal of Clinical Investigation·B F HaynesJ A Bartlett
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z Q ZhangA T Haase
Mar 11, 2000·The Journal of Clinical Investigation·J M McCuneM Hellerstein
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S S HuangJ M McCune
Sep 28, 2002·AIDS·Hernan ValdezUNKNOWN AIDS Clinical Trials Group Protocol 375 Team
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ruy M RibeiroAlan S Perelson

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Citations

Jan 24, 2012·International Journal of Nanomedicine·Shantanu BalkundiHoward E Gendelman
Jul 4, 2009·Nanomedicine·Ari Nowacek, Howard E Gendelman
Jul 10, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Borislav SavkovicJohn M Murray
Jun 21, 2011·American Journal of Clinical Pathology·Julián ArceHoward Ratech
Apr 3, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sam KalungiLeif Bostad
Dec 30, 2014·Immunobiology·Cristina Menezes GattoniSanívia Aparecida de Lima Pereira
Jul 23, 2016·IET Systems Biology·E Fabian CardozoRyan Zurakowski
May 2, 2007·Clinical Orthopaedics and Related Research·S DanaviahS Cassol
Jan 31, 2018·Retrovirology·Javier Martinez-PicadoMario Stevenson
Sep 6, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marta GarridoLlucia Alos
Jul 1, 2010·AIDS·Alba DiazUNKNOWN Study Group of Lymphoid Tissue immunopathogenesis in HIV infection
Mar 17, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pål VoltersvikBirgitta Asjö
May 5, 2006·Advances in Dental Research·M C HerzbergS M Wahl
Aug 10, 2011·Current Opinion in HIV and AIDS·Georg HuberHeribert Stoiber
Apr 19, 2013·AIDS·Sylvie AmuFrancesca Chiodi

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