PMID: 6971938Jan 1, 1981Paper

Immunobiology of D-penicillamine

The Journal of Rheumatology. Supplement
R L DawkinsB L McDonald

Abstract

D-penicillamine holds the key to a better understanding of autoimmunization and the pathogenesis of autoimmune disease. Analysis of its mode of action is complicated by its multiplicity of effects. In respect to anti-acetylcholine receptors and myasthenia gravis, the major effect may be at the level of immunoregulation and/or immunogenicity. Anti-striated muscle antibody is much more common and is influenced by the HLA antigen of the patient. Thus, HLA-linked immune response genes may be involved.

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