Immunobiology of face transplantation

The Journal of Craniofacial Surgery
David A LeonardCurtis L Cetrulo

Abstract

Fourteen face transplants have been performed worldwide since the procedure was successfully introduced in 2005. Vascularized composite tissue allotransplantation may now be considered a viable option for the repair of complex craniofacial defects, for which the results of autologus reconstruction remain suboptimal. However, the benefits must be balanced against the risks inherent in major surgery and the adverse effects of lifelong immunosuppression. In this article, we review the current practice and areas of controversy in facial vascularized composite tissue allotransplantation with particular respect to the unique immunobiology of this procedure. We also describe promising recent advances in immunotherapy and tolerance induction strategies that may soon reach clinical application.

References

May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Sykes, D H Sachs
Jul 3, 2010·Plastic and Reconstructive Surgery·Maria Z SiemionowChad R Gordon

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Citations

Aug 17, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·Kumaran ShanmugarajahPeter E M Butler
Sep 24, 2015·Burns : Journal of the International Society for Burn Injuries·H J KleinJ A Plock
Mar 24, 2015·The Journal of Laryngology and Otology·G L GarrettA D'souza
Jul 13, 2016·Facial Plastic Surgery Clinics of North America·Jack E Russo, Eric M Genden
Jan 29, 2017·International Journal of Surgery·Mark A HardyJohn H Barker
Dec 28, 2016·The Journal of Craniofacial Surgery·Samuel GolpanianSeth R Thaller
Nov 5, 2015·Current Opinion in Organ Transplantation·Luccie WoBohdan Pomahac
Mar 23, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Zhi Yang NgCurtis L Cetrulo
Feb 9, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Sotirios TasigiorgosBohdan Pomahac
Oct 20, 2012·Expert Review of Clinical Immunology·Gerald BrandacherStefan Schneeberger

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