PMID: 9525773Apr 3, 1998Paper

Immunobiology of lipopolysaccharide (LPS) and LPS-derived immunoconjugates vaccinate mice against Salmonella typhimurium

Microbiology and Immunology
R P TiwariPraveen Rishi

Abstract

The immunobiology of lipopolysaccharide (LPS) of Salmonella typhimurium LT2-71 was studied in its native, modified and conjugated states using mice as the experimental model. An alkali-treated detoxified fraction of LPS (D-LPS) was found to be not only non-toxic but also equally immunogenic, like LPS. In addition D-LPS alone or conjugated with enterotoxin or hemolysin was also non-pyrogenic and non-indurogenic. The immunoprophylactic activity of D-LPS conjugates to a 100 ID50 challenge dose of S. typhimurium was also higher than that of detoxified LPS or native LPS.

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Citations

May 23, 2009·Biological Trace Element Research·Praveen RishiRam Prakash Tiwari
Jul 15, 2005·Molecular and Cellular Biochemistry·Shaloo SoodNirmal Kumar Ganguly

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