PMID: 8988868Nov 1, 1996Paper

Immunobiology of pseudorabies (Aujeszky's disease)

Veterinary Immunology and Immunopathology
T C Mettenleiter

Abstract

Aujeszky's Disease (AD), a serious illness of pigs causing significant economic losses in the pig industry, is caused by Pseudorabies Virus (PrV). PrV belongs to the alphaherpesvirus subfamily of the herpesviruses with a double-stranded DNA genome in an enveloped capsid capable of encoding approximately 70 proteins. For disease control, vaccination with live and killed vaccines is performed. Recently, 'marked' vaccines have become available for use in eradication programs based on the differentiation between infected and vaccinated animals. PrV is also used as a viral vector for the development of multivalent vaccines. Despite the effectiveness of PrV vaccines, relatively little is known about the immune response against PrV infection. Several viral envelope glycoproteins have been shown to represent targets for antibody responses, and a number of isolated glycoproteins as well as genetically engineered proteins were able to elicit protective immunity. The nature of the cellular immune response is even less defined. Using viral mutants genetically engineered to lack specific antigens, it has been shown that glycoprotein C (gC) acts as a target for cytotoxic T-lymphocytes, and gB, gC, gD, and gH appear to be involved in stimulat...Continue Reading

References

May 1, 1990·The Journal of General Virology·W FuchsT C Mettenleiter
May 1, 1994·Journal of Comparative Pathology·M NaritaY Miura
Jul 1, 1993·Veterinary Microbiology·T NakamuraS Ueda

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Citations

Mar 13, 2002·Veterinary Microbiology·G Van MinnebruggenM B Pensaert
May 1, 1999·Veterinary Microbiology·V GerdtsT C Mettenleiter
Jun 27, 2013·Animal Health Research Reviews·Randall L Levings, James A Roth
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marija BackovicFelix A Rey
Jun 16, 2006·Journal of Virology·L M OlsenL W Enquist
May 9, 2000·Journal of Virology·P DietzT C Mettenleiter
Sep 9, 2005·Microbiology and Molecular Biology Reviews : MMBR·Lisa E PomeranzChristoph J Hengartner
Jan 18, 2005·Vaccine·Daniela TudorSabine Riffault
Jul 17, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Dongfang HuSidang Liu
Feb 24, 2018·Transboundary and Emerging Diseases·J GuY Xiao
Oct 20, 2017·Journal of Virology·Melina VallbrachtMarija Backovic
Oct 26, 2018·Journal of Virology·Jonathan L MillerAnthony V Nicola
Mar 12, 2010·Clinical and Vaccine Immunology : CVI·Laura C MillerKelly M Lager
Jan 5, 2016·Journal of Veterinary Science·Dongfang HuSidang Liu
Oct 15, 2021·Viral Immunology·Li ZhangMinghua Yan

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