Immunobiotic Lactobacillus jensenii modulates the Toll-like receptor 4-induced inflammatory response via negative regulation in porcine antigen-presenting cells.

Clinical and Vaccine Immunology : CVI
Julio VillenaHaruki Kitazawa

Abstract

Previously, we demonstrated that Lactobacillus jensenii TL2937 attenuates the inflammatory response triggered by activation of Toll-like receptor 4 (TLR-4) in porcine intestinal epithelial cells. In view of the critical importance of antigen-presenting cell (APC) polarization in immunoregulation, the objective of the present study was to examine the effect of strain TL2937 on the activation patterns of APCs from swine Peyer's patches (PPs). We demonstrated that direct exposure of porcine APCs to L. jensenii in the absence of inflammatory signals increased expression of interleukin-10 (IL-10) and transforming growth factor β in CD172a(+) APCs and caused them to display tolerogenic properties. In addition, pretreatment of CD172a(+) APCs with L. jensenii resulted in differential modulation of the production of pro- and anti-inflammatory cytokines in response to TLR4 activation. The immunomodulatory effect of strain TL2937 was not related to a downregulation of TLR4 but was related to an upregulation of the expression of three negative regulators of TLRs: single immunoglobulin IL-1-related receptor (SIGIRR), A20, and interleukin-1 receptor-associated kinase M (IRAK-M). Our results also indicated that TLR2 has an important role in t...Continue Reading

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Nov 19, 2013·Seminars in Immunology·Cecilia GarlandaAlberto Mantovani
Apr 18, 2014·Journal of Applied Microbiology·T S KemgangR Kapila
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Dec 12, 2020·Food Science of Animal Resources·Vijitra Luang-InNyuk Ling Ma
Jun 1, 2021·Frontiers in Immunology·José María Lemme-DumitCarolina Maldonado-Galdeano
Aug 21, 2021·Frontiers in Pharmacology·Alexander A Andreev-AndrievskiyVladimir G Nesterenko

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