PMID: 7541835Apr 1, 1995Paper

Immunochemical characterization of neural cell adhesion molecule (NCAM), nitric oxide synthase, and neurofilament protein expression in pyloric muscle of patients with pyloric stenosis

Journal of Pediatric Gastroenterology and Nutrition
H KobayashiP Puri

Abstract

The etiology of hypertrophic pyloric stenosis (HPS) is not known. We made an immunocytochemical examination of pyloric muscle from 18 patients with HPS and 10 controls using specific monoclonal antibodies to neural cell adhesion molecule (NCAM) as well as neurofilament protein and NADPH-diaphorase histochemistry. In HPS, bundles of hypertrophic muscle fibers expanded the circular muscle layer. The longitudinal muscle also appeared hypertrophic but to a less marked degree. The most striking difference between HPS and the control tissues was that NCAM, NADPH-diaphorase, and neurofilament protein immunoreactive fibers were absent or markedly reduced within the hypertrophied circular and longitudinal musculature. In contrast, NCAM, NADPH-diaphorase, and neurofilament protein immunoreactivity was preserved in the myenteric plexus where nerve fibers and ganglion cells were stained. The lack of expression of NCAM, NADPH-diaphorase, and neurofilament protein on nerve fibers within the circular and longitudinal muscle in patients with pyloric stenosis suggests that the smooth muscle is not innervated in this condition.

Citations

Sep 27, 2006·Pediatric Surgery International·Thambipillai Sri ParanPrem Puri
Oct 31, 2007·Pediatric Surgery International·Udo RollePrem Puri
Sep 18, 2009·Pediatric Surgery International·Christina Panteli
Jan 20, 1998·Journal of Pediatric Surgery·H KobayashiP Puri
Jul 11, 2012·Nature Reviews. Gastroenterology & Hepatology·Babette PeetersRaoul C M Hennekam
Aug 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·A C Dick, J A Dodge
Jul 9, 2010·World Journal of Gastroenterology : WJG·Randa-M MostafaHosam Hamdy
Sep 8, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L R RiveraJ B Furness
Apr 4, 2006·The Surgical Clinics of North America·Bindi Naik-Mathuria, Oluyinka O Olutoye
Dec 22, 1999·Microscopy Research and Technique·J M Vanderwinden, J J Rumessen
Mar 26, 2002·Journal of Pediatric Surgery·Udo RollePrem Puri
Jun 29, 2000·Journal of Pediatric Surgery·N GuarinoP Puri

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