PMID: 6965607Mar 15, 1980Paper

Immunochemical detection of fecal occult blood--the fecal smear punch-disc test: a new non-invasive screening test for colorectal cancer

Cancer
C L SongsterD D Jarrett

Abstract

An immunochemical test for fecal occult blood was developed for use in colon cancer screening. The test employs high titer monospecific antisera to intact human hemoglobin in a radial immunodiffusion assay. Patient smears on specially treated filter paper allow screening procedures similar to those using Hemoccult slides. Minimum detectible hemoglobin was 0.3 mg/gm stool, and no cross reactivity with dietary constituents, drugs, or chemicals occurred. The accession of 150 consecutive cases of colon-rectal carcinoma was accomplished from three community hospitals. In each instance, at least one preoperative fecal specimen was obtained for companion smear testing with immunochemical punch-disc and commercial Hemoccult slides. Twenty-nine percent of the cases were found not to be bleeding by either test. Occult bleeding was detected by Hemoccult in 40% of the cases, and occult bleeding was detected by immunochemical testing in 65% of the cases. A surprising discovery was that rectal lesions had a much lower rate of of positiuity with both tests (Hemoccult-29%, Immunochemical-50%) than other locations. These results suggest that immunochemical screening for occult blood loss will provide a higher rate of detection of colon cancer.

References

Mar 1, 1978·American Journal of Clinical Pathology·G H BarrowsC L Songster
Jan 1, 1976·CA: a Cancer Journal for Clinicians·H SeidmanA I Holleb
Dec 1, 1975·Annals of Internal Medicine·R M JaffeJ D MacLowry
Jul 31, 1971·Lancet·H Lehmann, E G Kitchin
Nov 1, 1972·CA: a Cancer Journal for Clinicians·D H Greegor
Feb 1, 1974·American Journal of Surgery·J B Hastings
Nov 1, 1969·CA: a Cancer Journal for Clinicians·D H Greegor
Dec 1, 1965·Gut·D G Illingworth
Mar 1, 1966·Southern Medical Journal·N P Trujillo, H E Ticktin
Nov 20, 1967·JAMA : the Journal of the American Medical Association·H D Markman
Sep 18, 1967·JAMA : the Journal of the American Medical Association·D H Greegor

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Citations

Apr 16, 1988·British Medical Journal·D J FrommerM K Brown
Aug 15, 1981·British Medical Journal·C D GriffithJ H Saunders
Sep 8, 2010·International Journal of Health Geographics·Lee R MobleySujha Subramanian
Oct 1, 1985·Scandinavian Journal of Gastroenterology·N GabrielssonB Nilsson
Mar 1, 1990·Scandinavian Journal of Primary Health Care·J Månsson
Oct 1, 1991·Annals of Medicine·O Kronborg
Mar 24, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Leo G M van Rossum
Feb 1, 1982·Current Problems in Cancer·J S Spratt
Apr 1, 1984·Australian and New Zealand Journal of Medicine·C A McDonaldK J Goulston
Dec 1, 1987·The Australian and New Zealand Journal of Surgery·J A WilliamsA Sen
Oct 1, 1985·The Australian and New Zealand Journal of Surgery·J A WilliamsT W Huber
Jan 1, 1987·The British Journal of Surgery·P G Reasbeck
Jan 1, 1986·Seminars in Surgical Oncology·C Mettlin, K M Cummings
May 1, 1995·Gastrointestinal Endoscopy·Y Uno, A Munakata
Oct 1, 1996·Japanese Journal of Cancer Research : Gann·H Saito
Nov 23, 2000·Journal of Surgical Oncology·S Ottó, S Eckhardt
Jul 4, 1991·The New England Journal of Medicine·D F Ransohoff, C A Lang
May 30, 1985·The New England Journal of Medicine·D A AhlquistR A Owen
May 1, 1989·Cancer·D A AhlquistC G Moertel
Apr 28, 2017·Journal of Primary Care & Community Health·Jeanette M DalyBarcey T Levy
Jan 1, 1983·American Journal of Surgery·S J SontagH B Greenlee
May 1, 1988·Digestive Diseases and Sciences·L BertarioF Berrino
Jan 1, 1982·Medical Decision Making : an International Journal of the Society for Medical Decision Making·P DoubiletS G Pauker
Jan 1, 1987·Cancer Metastasis Reviews·J B Simon
Aug 15, 1981·British Medical Journal·F M Messahel, P J Tomlin
Dec 1, 1982·The Australian and New Zealand Journal of Surgery·J A WilliamsD W Thomas
Jun 1, 1983·Irish Journal of Medical Science·B Herity
May 21, 2013·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Jeanette M DalyBarcey T Levy
Nov 13, 2013·Current Gastroenterology Reports·Lukejohn W DayJames Allison
Oct 12, 2019·Critical Reviews in Clinical Laboratory Sciences·Erika Hissong, Meredith E Pittman
Feb 13, 2015·Current Gastroenterology Reports·Sally C BentonStephen P Halloran
Oct 29, 2000·Diseases of the Colon and Rectum·H Saito
Aug 23, 2011·Scandinavian Journal of Gastroenterology·Hans J NielsenUNKNOWN Danish Study Group on Early Detection of Colorectal Cancer
Apr 1, 1986·International Journal of Colorectal Disease·F MacraeJ B Simon

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