Sep 30, 1985

Immunochemical examinations of cytochrome P-450 in various tissues of human fetuses using antibodies to human fetal cytochrome P-450, P-450 HFLa

Biochemical and Biophysical Research Communications
M KitadaY Kanakubo

Abstract

P-450 HFLa is a form of cytochrome P-450 purified from human fetal livers. The amounts of P-450 HFLa in several fetal tissues were determined immunochemically. Detectable amounts presented in livers, kidneys, adrenals, lungs and some other tissues of human fetuses. The amounts were the highest in livers. Activities of 7-ethoxycoumarin O-deethylase and benzo(a)pyrene hydroxylase in livers but not in adrenals were inhibited by the anti-P-450 HFLa antibodies, probably suggesting that distinct forms of cytochrome P-450 are responsible for the oxidations in livers and adrenals.

  • References8
  • Citations14

Mentioned in this Paper

Fetal Structures
Lung
Spleen
Cytochrome P450
Ovary
Benzopyrene Hydroxylase
Kidney
Cytochrome P-450 Oxygenase
Oxidation
Both Kidneys

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