PMID: 5905240Feb 1, 1966

Immunochemical study of antigenic specificity in delayed hypersensitivity. V. Immunization with monovalent low molecular weight conjugates

The Journal of Experimental Medicine
S LeskowitzS J Zak

Abstract

Hapten-specific delayed hypersensitivity was produced by immunization of guinea pigs with arsanilic acid conjugated to N-acetyltyrosine or other small aromatic molecules. Such hapten-specific delayed sensitivity could be passively transferred by peritoneal exudate cells. While a conjugate made from a polymer of D-amino acids was ineffective in producing sensitization, the conjugate made with D-tyrosine was effective, suggesting that the inability of D-amino acid polymers to be broken down by enzymes might be bypassed by use of the monomer. The effectiveness of such monomers in producing delayed sensitivity, but not antibody production, is consistent with a hypothesis that different types of antigenic determinants are involved in the production of each.

Citations

Apr 1, 1969·Die Naturwissenschaften·M Sela
Jan 1, 1987·Immunology Today·M W Steward, C R Howard
Apr 5, 1969·Nature·C Collotti, S Leskowitz
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·N KochibeS C Kinsky
Apr 1, 1968·The Journal of Experimental Medicine·M B Rittenberg, D H Campbell
Nov 1, 1969·The Journal of Experimental Medicine·J R FreyW Lergier
Mar 1, 1970·The Journal of Experimental Medicine·C Collotti, S Leskowitz
Sep 1, 1970·The Journal of Experimental Medicine·H B RichersonS Leskowitz
Dec 1, 1972·The Journal of Experimental Medicine·M E BushJ W Goodman
Sep 1, 1978·The Journal of Experimental Medicine·S FongJ W Goodman
Jan 1, 1970·Transplantation Reviews·W E Paul
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Jan 1, 1978·Annals of the New York Academy of Sciences·S C Kinsky
Jan 1, 1974·The Journal of Clinical Investigation·K L MelmonS Bauminger
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Jan 1, 1975·The International Journal of the Addictions·B N Kinder
Jul 1, 1977·European Journal of Immunology·T Jorgensen, K Hannestad

Related Concepts

Antigens
Arsenicals
Exudates and Transudates
Cavia porcellus
Haptens
Delayed Hypersensitivity
Immunochemistry
Visceral Peritoneum
Tyrosine

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