PMID: 5905240Feb 1, 1966

Immunochemical study of antigenic specificity in delayed hypersensitivity. V. Immunization with monovalent low molecular weight conjugates

The Journal of Experimental Medicine
S LeskowitzS J Zak


Hapten-specific delayed hypersensitivity was produced by immunization of guinea pigs with arsanilic acid conjugated to N-acetyltyrosine or other small aromatic molecules. Such hapten-specific delayed sensitivity could be passively transferred by peritoneal exudate cells. While a conjugate made from a polymer of D-amino acids was ineffective in producing sensitization, the conjugate made with D-tyrosine was effective, suggesting that the inability of D-amino acid polymers to be broken down by enzymes might be bypassed by use of the monomer. The effectiveness of such monomers in producing delayed sensitivity, but not antibody production, is consistent with a hypothesis that different types of antigenic determinants are involved in the production of each.


Apr 1, 1969·Die Naturwissenschaften·M Sela
Jan 1, 1987·Immunology Today·M W Steward, C R Howard
Apr 5, 1969·Nature·C Collotti, S Leskowitz
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·N KochibeS C Kinsky
Apr 1, 1968·The Journal of Experimental Medicine·M B Rittenberg, D H Campbell
Nov 1, 1969·The Journal of Experimental Medicine·J R FreyW Lergier
Mar 1, 1970·The Journal of Experimental Medicine·C Collotti, S Leskowitz
Sep 1, 1970·The Journal of Experimental Medicine·H B RichersonS Leskowitz
Dec 1, 1972·The Journal of Experimental Medicine·M E BushJ W Goodman
Sep 1, 1978·The Journal of Experimental Medicine·S FongJ W Goodman
Jan 1, 1970·Transplantation Reviews·W E Paul
Jan 1, 1974·Transplantation Reviews·W W Bullock, E Möller
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Jan 1, 1978·Immunological Reviews·W W Bullock
Jan 1, 1978·Immunological Reviews·J W GoodmanG Der Balian
Feb 13, 1970·Annals of the New York Academy of Sciences·M Sela
Jan 1, 1978·Annals of the New York Academy of Sciences·S C Kinsky
Jan 1, 1974·The Journal of Clinical Investigation·K L MelmonS Bauminger
Jan 1, 1973·Immunological Communications·P D LeberS Cohen
Mar 1, 1970·Angewandte Chemie·E Rüde
Jul 15, 1980·Cellular Immunology·A Ray, S Ben-Sasson
Jul 1, 1973·Cellular Immunology·N HannaS Leskowitz
Mar 1, 1987·Biochemical Pharmacology·B K ParkN R Kitteringham
Oct 1, 1979·European Journal of Immunology·F Y LiewC M Brand
Feb 1, 1974·European Journal of Immunology·K Rajewsky, R Mohr
Aug 1, 1971·European Journal of Immunology·C Nauciel, M Raynaud
Mar 8, 1984·Nature·N A Mitchison
Jan 1, 1975·The International Journal of the Addictions·B N Kinder
Jul 1, 1977·European Journal of Immunology·T Jorgensen, K Hannestad

Related Concepts

Exudates and Transudates
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Delayed Hypersensitivity
Visceral Peritoneum

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