PMID: 7370952Apr 15, 1980Paper

Immunocompetence, immunosuppression, and human breast cancer. II. Further evidence of initial immune impairment by integrated assessment effect of nodal involvement (N) and of primary tumor size (T)

Cancer
A AdlerS Ben-Efraim

Abstract

Comprehensive immune function by integrated score was assessed in 158 operable, 55 inoperable, and 52 metastatic breast cancer patients relative to 107 healthy controls. The score was derived from in vivo response to PPD and DNCB and in vitro lymphocyte stimulation by PPD and PHA. Proportion of E-RFC was significantly lower in patients than in controls but was not found to correlate directly with the above functional criteria. Fifty-one percent of the patients with early, operable tumors were shown to be at least partially immunosuppressed by integrated score achievement vs. 11% of controls. This proportion rises to 68% of inoperable and 89% of metastatic patients. Quantitative analysis by graded response revealed an additional, significant degree of immune impairment in the respective patient groups by all testing parameters. Depression of immune function in operable patients was not related to age nor influenced by surgery. Immunocompetence of patients with mammary dysplasia did not differ from controls. Increasing size of primary tumor (T) was not found to be matched by progressive degree of immunosuppression, excepting that associated with large T4 tumors. Patients with lymph node involvement (N+) were not significantly imm...Continue Reading

References

Jan 1, 1978·British Journal of Cancer·R H WhiteheadJ Thatcher
Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·T R JerrellsR B Herberman
May 1, 1971·Lancet·M G WhittakerC G Clark
Jul 1, 1974·The British Journal of Surgery·M M Roberts, W Jones-Williams
Sep 1, 1968·British Journal of Cancer·I M Hamlin

❮ Previous
Next ❯

Citations

Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·M NielsenJ A Andersen
Feb 21, 2006·Biotechnology Letters·Seong Lyul RhimGeun Eog Ji
Jul 9, 2002·The Breast Journal·Liron Pantanowitz, James L Connolly
Jan 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ming ZhaoRobert M Hoffman
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ming ZhaoRobert M Hoffman
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·L H DangB Vogelstein
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·R K Jain, N S Forbes
Apr 1, 1984·The Journal of Clinical Investigation·D G HesseR C Williams
Mar 29, 2014·BioMed Research International·Su-Eon JinSoon-Sun Hong
Jan 1, 1994·Cancer Investigation·E M Greenspan
Nov 17, 2015·Immunotherapy·Guy T CliftonGeorge E Peoples

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.