PMID: 7370953Apr 15, 1980Paper

Immunocompetence, immunosuppression, and human breast cancer. III. Prognostic significance of initial level of immunocompetence in early and advanced disease

Cancer
A AdlerS Ben-Efraim

Abstract

The prognostic significance of immunocompetence determined at diagnosis was analyzed in 158 operable breast cancer patients followed for 3--6 years, in terms of disease recurrence and of length of disease-free period (DFP) and in 52 patients with metastatic disease in terms of length of survival. In vitro lymphocyte stimulation by PPD and PHA were of higher predictive value with respect to probability of disease recurrence than in vivo cutaneous reactivity to PPD and DNCB. Conversely, length of DFP and of survival were found to correlate better with in vivo than within vitro parameters. Absolute number of peripheral blood lymphocytes (PBL) and percent of E-rosette-forming cells (E-RFC) proved devoid of prognostic value. Prognostic separation was best brought out upon analysis by integrated score of immunocompetence, comprising the four functional parameters. Probability of disease recurrence was 0.43 for all operable patients, as calculated by actuarial method 48 months postoperatively; it was 0.26 for optimal and 0.61 for suboptimal responders (P less than 0.0001). Separate analysis of Stage 1 (N0) and Stage II (N+) patients revealed prognostic segregation within each stage: probability of recurrence in Stage I was 0.06 for op...Continue Reading

References

Jul 19, 1975·Lancet·D Brinkley, J L Haybrittle
Feb 15, 1977·International Journal of Cancer. Journal International Du Cancer·S MénardG D Porta
Feb 15, 1977·International Journal of Cancer. Journal International Du Cancer·M I ColnaghiG D Porta
Oct 15, 1977·International Journal of Cancer. Journal International Du Cancer·B M VoseE Klein
Jan 1, 1976·Journal of the National Cancer Institute·F AvisG Haughton
Dec 12, 1974·The New England Journal of Medicine·A H GlasgowJ A Mannick
Feb 1, 1974·Cancer·P L TwomeyP B Chretien
Sep 1, 1968·British Journal of Cancer·I M Hamlin

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Citations

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·R ValavaaraA Toivanen
Jul 9, 2002·The Breast Journal·Liron Pantanowitz, James L Connolly
Jun 14, 2003·Journal of Hematotherapy & Stem Cell Research·John O OjeifoKenneth R Meehan
Dec 1, 1994·The Australian and New Zealand Journal of Surgery·W J AdamsL Peters
Feb 10, 2007·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Massimo Pasquini, Massimo Biondi
Mar 24, 2011·Expert Review of Clinical Immunology·Susumu Ikehara
Jan 1, 1993·Cancer Investigation·M E Sabbioni
Jan 1, 1986·Cancer Investigation·E M Greenspan
May 4, 2010·Cellular Immunology·David KoosEwa Carrier
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J LukacN Daković
Mar 17, 2004·Psycho-oncology·Richard H OsborneAndrew J Sinclair
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Keren ShakharDana H Bovbjerg
Jan 1, 1992·Critical Reviews in Oncology/hematology·R ClarkeM E Lippman

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