Immunocorrecting properties of GB-115 dipeptide

Bulletin of Experimental Biology and Medicine
E V ShipaevaS B Seredenin

Abstract

We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1-10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.

References

Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Jun 27, 2002·Current Urology Reports·B J GitlitzA S Belldegrun
Aug 12, 2003·Bulletin of Experimental Biology and Medicine·N V MasnayaE Yu Sherstoboev

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Citations

Jan 12, 2012·Bulletin of Experimental Biology and Medicine·E V ShipaevaS B Seredenin
Jun 25, 2014·Bulletin of Experimental Biology and Medicine·I E IgnatovaD D Karal-Ogly

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