Immunocyt and the HA-HAase urine tests for the detection of bladder cancer: a side-by-side comparison

European Urology
Stefan H HautmannVinata B Lokeshwar

Abstract

The reliable detection of bladder cancer from urine specimen remains an unsolved problem. Especially superficial bladder cancer can be missed with urine tests. We assessed the sensitivity and specificity of the commercial Immunocyt test in a side-by-side comparison with the HA-HAase urine test and cytology. The Immunocyt test measures the immunocytological expression of sulfated mucin-glycoproteins and glycosylated forms of the carcinoembryonic antigen in urine. With the HA-HAase urine test the level of hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are measured in an ELISA-like test. A total of 94 consecutive patients were studied and among these 30 patients had bladder cancer and 64 were controls. Among bladder cancer patients, there were 14 pTa, 9 pT1, 5 pT2 and 2 carcinoma in situ (CIS) transitional cell carcinoma of the bladder, respectively. The controls consisted of 55 patients with a history of bladder cancer but no evidence of tumor at the follow-up cystoscopy and 9 benign prostatic hyperplasia (BPH) patients. The 30 transitional cell cancer specimens had 4 (13%) grade 1 tumors, 15 (50%) grade 2 tumors and 11 (37%) grade 3 tumors. Sensitivity and specificity as well as the positive and negative pre...Continue Reading

References

Apr 21, 1999·The Journal of Urology·C MianM Marberger
Mar 21, 2001·The Journal of Urology·V B Lokeshwar, M S Soloway
Jul 21, 2001·European Urology·I Kausch, A Böhle
Oct 26, 2001·Scandinavian Journal of Urology and Nephrology·H Olsson, B Zackrisson
Nov 22, 2001·The Journal of Biological Chemistry·Markku I TammiEva A Turley
Nov 22, 2001·The Journal of Biological Chemistry·Eva A TurleyLilly Y W Bourguignon
Feb 11, 2003·The Journal of Urology·Christian PfisterJean-Jacques Rambeaud
Aug 15, 2003·Current Opinion in Urology·Patrice Jichlinski
Sep 23, 2003·Current Opinion in Obstetrics & Gynecology·Sanaa EissaOmar El-Ahmady
Aug 12, 2004·International Journal of Cancer. Journal International Du Cancer·Sinan EkiciVinata B Lokeshwar

❮ Previous
Next ❯

Citations

Jul 6, 2006·Der Urologe. Ausg. A·D ZaakH Rübben
Oct 13, 2007·Der Urologe. Ausg. A·S HautmannK P Jünemann
Jun 27, 2009·Der Urologe. Ausg. A·S HautmannK P Juenemann
Jun 21, 2013·Der Urologe. Ausg. A·S TritschlerC Stief
Mar 13, 2013·Molecular Diagnosis & Therapy·Steve GoodisonVirginia Urquidi
May 24, 2007·Journal of Proteome Research·Paweena KreuninSteve Goodison
Jun 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bernard Têtu
Oct 9, 2008·Annual Review of Pathology·Anirban P Mitra, Richard J Cote
Feb 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Charles J RosserSteve Goodison
Oct 2, 2009·Future Oncology·Andrea B ApoloDean F Bajorin
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Melanie A Simpson, Vinata B Lokeshwar
Sep 21, 2013·Biomarkers in Medicine·Charles J RosserSteve Goodison
Apr 2, 2013·The Urologic Clinics of North America·Jeffrey M Tomasini, Badrinath R Konety
Oct 20, 2012·The Journal of Urology·Said F MishrikiBhaskar Somani
Nov 15, 2011·Colloids and Surfaces. B, Biointerfaces·Ki Young ChoiKinam Park
Jun 21, 2011·European Urology·Derya TilkiAlexandre R Zlotta
Nov 26, 2010·Human Pathology·Liang ChengRodolfo Montironi
Dec 29, 2007·European Urology·Olaf P J Vrooman, J Alfred Witjes
Nov 29, 2015·The Urologic Clinics of North America·Aurélie MbeutchaShahrokh F Shariat
Mar 21, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Olaf P J Vrooman, J Alfred Witjes
May 2, 2008·Seminars in Cancer Biology·Vinata B Lokeshwar, Marie G Selzer
Jul 5, 2006·Urologic Oncology·Badrinath R Konety
Feb 17, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Iman J SchultzJacques B de Kok
Dec 19, 2013·Case Reports in Urology·Seiichi Saito
Sep 19, 2006·Urology·Elenir B C AvritscherLinda S Elting
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter C BlackColin P Dinney
Nov 3, 2011·Therapeutic Advances in Urology·Rocco Damiano, Antonio Cicione
Jan 15, 2014·Urologia·Fabrizio Dal MoroFiliberto Zattoni
Jan 12, 2010·Nature Reviews. Urology·Anirban P Mitra, Richard J Cote
Oct 26, 2007·Archives of Pharmacal Research·De-Hai LiWei-Ming Zhu
Jul 1, 2008·Expert Review of Anticancer Therapy·Samir P Shirodkar, Vinata B Lokeshwar
Dec 5, 2008·Scandinavian Journal of Urology and Nephrology. Supplementum·Ellen C Zwarthoff
Oct 9, 2009·Expert Review of Proteomics·Steve GoodisonVirginia Urquidi
Jun 18, 2010·Expert Review of Anticancer Therapy·Liang ChengAntonio Lopez-Beltran
Jul 25, 2012·Current Opinion in Urology·Anirban P MitraRichard J Cote
Jun 22, 2012·Expert Review of Anticancer Therapy·Daniele CalistriDino Amadori
Jun 4, 2020·Cancers·Manuel Castanheira de OliveiraRicardo Ribeiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.