Immunocytochemical analysis of cyclic AMP receptor proteins in the developing rat parotid gland

Archives of Oral Biology
Maija MednieksArthur R Hand

Abstract

Previous studies showed that regulatory subunits of type II cyclic AMP-dependent protein kinase (RII) are present in adult rat parotid acinar cells, and are secreted into saliva. If the synthesis and intracellular distribution of RII exhibit developmental specificity, then RII can be an indicator of secretory and regulatory activity of salivary glands. To determine the expression and distribution of RII in the rat parotid at specific ages representing defined developmental stages. Parotid glands of fetal, neonatal and adult rats were prepared for morphologic and immunocytochemical study. The cellular distribution of RII was studied using light microscopic immunogold silver staining with anti-RII, and its intracellular distribution using electron microscopic immunogold labeling. In utero, parotid RII levels were low; 5-18 days after birth, labeling of secretory granules and cytoplasm rose to a peak, followed by a rapid decrease in both compartments at 25 days. At 60 days, granule labeling increased to levels near those at 18 days, whereas cytoplasmic labeling remained low. Nuclear labeling was highest during the first 3 weeks after birth, and then declined. The higher nuclear and cytoplasmic labeling during the neonatal period m...Continue Reading

References

Feb 1, 1978·Pediatric Research·R J Grand, M I Schay
Oct 1, 1979·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·R Taga, A Sesso
Jan 1, 1991·Progress in Nucleic Acid Research and Molecular Biology·D M CarlsonP S Wright
Mar 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M I MednieksA R Hand
Nov 1, 1974·Developmental Biology·L S Cutler, A P Chaudhry
Jun 1, 1973·The Anatomical Record·A Riva, F Riva-Testa
Jun 1, 1971·Developmental Biology·R S Redman, L M Sreebny
Sep 15, 1984·Experientia·M I Mednieks, A R Hand
Nov 1, 1983·Experimental Cell Research·M I Mednieks, A R Hand
Sep 1, 1993·Microscopy Research and Technique·B Tandler, C J Phillips
Nov 14, 1997·Biochemistry and Molecular Biology International·T TakumaT Ichida
Nov 12, 1998·The Anatomical Record·S SivakumarA R Hand
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y S ChoY S Cho-Chung
Sep 12, 2000·European Journal of Morphology·A SegawaA Riva
Apr 10, 2002·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·John C BurkeMaija I Mednieks
Apr 24, 2002·Experimental Cell Research·Giuseppe ServilloPaolo Sassone-Corsi
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M Melnick, T Jaskoll
Nov 7, 2002·The Journal of Biological Chemistry·Kim Are BirkeliKirsten Sandvig
Nov 9, 2002·European Journal of Biochemistry·Gareth J Browne, Christopher G Proud
Jun 14, 2003·Biochemical and Biophysical Research Communications·Rebecca L BrownStuart B Moss
Feb 3, 1965·Biochemical and Biophysical Research Communications·A BDOLAH, M SCHRAMM
Aug 11, 2004·Developmental Biology·Jiahu Wang, Gordon W Laurie
Aug 5, 2005·Journal of Cell Science·Lorene K Langeberg, John D Scott
Aug 19, 2006·Differentiation; Research in Biological Diversity·Vaishali N PatelMatthew P Hoffman
Aug 24, 2006·Journal of Cell Science·Eloy BejaranoAngel Velasco
Feb 24, 2007·Current Opinion in Cell Biology·Darren L Beene, John D Scott
Mar 6, 2007·Seminars in Cell & Developmental Biology·A S Tucker
Mar 10, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tetsuji NakamotoJames E Melvin
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hui WangRuiwen Zhang

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Citations

Aug 8, 2009·International Journal of Experimental Pathology·Maija I MednieksArthur R Hand
May 12, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Monica PirasMarco Piludu
Jul 10, 2018·European Journal of Oral Sciences·Didem DagdevirenArthur R Hand

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