PMID: 2500766Jan 1, 1989Paper

Immunocytochemical and morphometric analysis of acinar zymogen granules in human acute pancreatitis

Virchows Archiv. A, Pathological Anatomy and Histopathology
S WillemerGuido Adler

Abstract

In the present study fine structural changes of acinar zymogen granules were investigated in human acute pancreatitis. Pancreatic tissue was obtained at surgery from 6 patients, prepared for ultrastructural analysis, and stained immunocytochemically for trypsinogen. Stereological parameters of zymogen granules were evaluated. The density of the immunocytochemical labelling for trypsinogen was estimated over zymogen granules, the rough endoplasmic reticulum, Golgi apparatus and the acinar lumina. In acute pancreatitis the number of zymogen granules was diminished and their size reduced. The density of the labelling for trypsinogen was unchanged over zymogen granules but showed a significant reduction over the rough endoplasmic reticulum, Golgi apparatus, and the acinar lumina. In general the integrity of zymogen granules was well preserved. Focally degenerative changes of zymogen granules and large autophagosomes were observed. From the immunogold labelling a disturbance of enzyme synthesis and secretion was suggested. Evidence is given that a disruption of the zymogen granule membranes and a fusion with lysosomal bodies might contribute to the pathogenesis of human acute pancreatitis.

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Citations

Jan 1, 1990·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S WillemerG Adler
Aug 17, 2011·Current Opinion in Gastroenterology·Raghuwansh P Sah, Ashok Saluja
Aug 14, 2012·Current Opinion in Gastroenterology·Raghuwansh P SahAshok K Saluja
Dec 1, 1998·Pathology International·J KurodaY Hosokawa
Sep 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anna S Gukovskaya, Ilya Gukovsky
Mar 1, 1993·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A E AriasM Bendayan
Feb 1, 1991·Scandinavian Journal of Gastroenterology·R BialekG Adler
Aug 1, 1997·Drug and Chemical Toxicology·K E PhillipsA E Munson
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kim Hue SuChristopher Christophi
Apr 4, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xianbao ZhanBaoan Ji
Feb 15, 2020·Alcoholism, Clinical and Experimental Research·Toshimasa TakahashiHerbert Y Gaisano
Feb 12, 1998·The American Journal of Physiology·K MithöferA L Warshaw
Oct 18, 2007·The Journal of Biological Chemistry·Alejandro RopoloMaria I Vaccaro
Dec 1, 1997·Journal of Fish Biology·S EinarssonP Spencer Davies
Mar 31, 1998·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·A Brunelli, G Scutti
Feb 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·A J HietarantaT J Nevalainen
Jun 1, 1993·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·E TarpilaI Ihse

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