PMID: 7536281Jan 1, 1995Paper

Immunocytochemical characterization of malignant mesothelioma and carcinoma metastatic to the pleura: IOB3--a new tumor marker

Lung
C S KortsikH Matthys

Abstract

We have tried to find a reliable panel of markers that would allow distinction between mesotheliomas and carcinomas metastatic to the pleura. In a prospective study, we evaluated 54 pleural effusions: In 27 of the patients, a diagnosis of histologically proven metastatic carcinoma was subsequently established, 7 patients had biopsy-proven malignant mesotheliomas and 20 had benign, reactive effusions whose benign etiologies were established by more than 2 years clinical follow-up. The MAb (monoclonal antibody) IOB3 proved to be diagnostic for carcinomas in all 27 cases (100%), whereas CEA (carcinoembryonic antigen) expression was found in only 22 out of 27 (81%). None of the malignant mesotheliomas, nor benign reactive mesothelial cells reacted with these two markers. All carcinomas, as well as one malignant mesothelioma, reacted with the MAb HEA125. Antibodies against 12 single cytokeratins, vimentin, and EMA (epithelial membrane antigen) were not helpful in the differentiation between malignant mesotheliomas and malignant carcinomatous pleural effusions. We conclude that adding the antibody IOB3 to the CEA assay should allow a reliable differentiation between these two entities.

References

Mar 1, 1990·Journal of Clinical Pathology·U LatzaH Stein
Mar 12, 1991·International Journal of Cancer. Journal International Du Cancer·S S JoshiJ G Sharp
Aug 1, 1991·The American Journal of Surgical Pathology·K SheibaniL M Weiss
May 1, 1985·The American Journal of Surgical Pathology·A Churg
Dec 1, 1987·British Journal of Cancer·G MoldenhauerG J Hämmerling
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·P MöllerH F Otto
Dec 31, 1965·Annals of the New York Academy of Sciences·W T McCaughey

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Citations

Sep 1, 1996·The American Journal of Surgical Pathology·C DoglioniG Viale
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society
Jun 19, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·G MetzgerothJ Hastka
Jul 6, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·D Whitaker
Sep 4, 1998·Cancer Detection and Prevention·B NismanJ Lafair
Jan 9, 2016·The International Journal of Biological Markers·Wentao LinYing Cen

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