Immunocytochemical correlation of peptides and tyrosine hydroxylase in nerve fibres of the human parotid gland

Archives of Oral Biology
C HeymD Adler

Abstract

The peptidergic innervation of parenchymal and vascular components in the human parotid gland was investigated by double-labelling fluorescence. Peptide immunoreactivity in nerve fibres was correlated with the presence of tyrosine hydroxylase (TH). By light microscopy, acinar innervation consisted of fibres with the combinations neuropeptide Y (NPY)/TH and NPY/vasoactive intestinal polypeptide (VIP). Some fibres were solely NPY, TH or VIP immunoreactive. Rarely, substance P (SP)/calcitonin gene-related (CGRP)-immunolabelled fibres were associated with acini. Intercalated ducts were often approached by NPY/TH- and VIP-containing fibres. VIP innervation of excretory ducts was sparse. Intralobular and intralobar excretory ducts, in addition to NPY and TH, revealed CGRP and CGRP/SP innervation, whereas nerve fibres on interlobar excretory ducts very rarely contained NPY and none of the other mediators. Vascular innervation consisted of NPY/TH and SP/CGRP fibres; in a few fibres SP was colocalized with leu-enkephalin. Large arteries were encircled by some VIP-positive fibres. The findings suggest a specific participation of neuropeptides and of peptide combinations in the regulation of parotid exocrine function.

References

Aug 1, 1979·Acta Physiologica Scandinavica·H E BannsS P Mann
Jan 1, 1979·British Journal of Pharmacology·S R Bowen, F G Carpenter
Jul 15, 1987·Experientia·T HökfeltT Bartfai
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May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G G LeblancS C Landis
Sep 1, 1983·The Journal of Physiology·D V Gallacher

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