PMID: 15387374Sep 25, 2004Paper

Immunocytochemical demonstration of down regulation of HLA class-I molecule expression in human metastatic breast carcinoma

Clinical & Experimental Metastasis
Masanao SaioAlan B Frey

Abstract

Deficient expression of HLA class-I molecules observed in many cancers is suggested to influence both disease progression and potential efficacy of T cell-mediated immune therapy. Previous studies have attempted to correlate either primary breast cancer tumor grade with HLA class-I levels or the presence of HLA class-I-deficient cells in metastatic lesions with survival. In this study we evaluated the HLA class-I status of matched primary and secondary breast cancer lesions in order to ask the question: is metastasis of breast cancer associated with down-regulation of HLA class-I expression? Immunocytochemistry analysis shows a definitive correlation between diminished HLA class-I expression and dissemination of breast cancer to tumor-draining lymph nodes: both the total number of HLA class-I+ cells per sample and the levels of expression are dramatically decreased in secondary versus primary tumor lesions. These findings are consistent with the contention that the ability of breast cancer cells to escape the confines of the original tumor lesion requires down-regulation of HLA class-I expression and implies that enhancing HLA class-I expression in secondary breast cancer may have a beneficial effect on T-cell-mediated immunoth...Continue Reading

Citations

May 14, 2005·Cancer Immunology, Immunotherapy : CII·Keith L KnutsonMary L Disis
Jul 15, 2009·Journal of Translational Medicine·Courtney SmithStanislav Vukmanovic
Jan 25, 2011·Journal of Experimental & Clinical Cancer Research : CR·Caigan Du, Yuzhuo Wang
Dec 5, 2014·International Journal of Cancer. Journal International Du Cancer·Federico GarridoAngel M Garcia-Lora
Feb 13, 2018·Frontiers in Immunology·Irene RomeroAngel M Garcia-Lora
Apr 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oriana HawkinsJon Weidanz
Mar 27, 2021·Frontiers in Immunology·Karthik DhatchinamoorthyKenneth L Rock

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