PMID: 2499109Jan 1, 1989Paper

Immunocytochemical demonstration of IGF-II-like immunoreactivity in human paraganglioma of the craniocervical region

Virchows Archiv. A, Pathological Anatomy and Histopathology
T SuzukiN Yanaihara

Abstract

Insulin-like-growth factor (IGF)-II-like immunoreactivity was examined in two carotid bodies and six extra-adrenal paragangliomas with use of monoclonal antibody against rat IGF-II, which crossreacts with human IGF-II. Chief cells but not sustentacular cells of the carotid body were positive at about 10% in one case and less than 1% in another case. Among four carotid body tumours, a possible vagal body tumour and one glomus jugulare tumour, all but the glomus jugulare tumour exhibited positive tumour cells irrespective of histological variations. The frequency of positive cells ranged from 20 to 60%. IGF-II like immunoreactivity, therefore, might be widely distributed in human extra-adrenal paraganglionic tissues and tumours, although its biological role in these cells remains to be elucidated.

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Citations

Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M z ChengL E Lanyon
Apr 2, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ming Zhao ChengLance E Lanyon
Feb 24, 2001·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·S OginoM L Cohen
Oct 7, 2020·International Journal of Molecular Sciences·Elena StoccoAndrea Porzionato

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