PMID: 7026573Aug 1, 1981Paper

Immunocytochemical demonstration of vimentin in astrocytes and ependymal cells of developing and adult mouse nervous system

The Journal of Cell Biology
J SchnitzerM Schachner

Abstract

The occurrence of vimentin, a specific intermediate filament protein, has been studied by immunoflourescence microscopy in tissue of adult and embryonic brain as well as in cell cultures from nervous tissue. By double imminofluorescence labeling, the distribution of vimentin has been compared with that of subunit proteins of other types of intermediate filaments (glial fibrillary acidic [GFA] protein, neurofilament protein, prekeratin) and other cell-type specific markers (fibronectin, tetanus toxin receptor, 04 antigen). In adult brain tissue, vimentin is found not only in fibroblasts and cells of larger blood vessels but also in ependymal cells and astrocytes. In embryonic brain tissue, vimentin is detectable as early as embryonic day 11, the earliest stage tested, and is located in radial fibers spanning the neural tube, in ventricular cells, and in blood vessels. At all stages tested, oligodendrocytes and neurons do not express detectable amounts of vimentin. In primary cultures of early postnatal mouse cerebellum, a coincident location of vimentin and GFA protein is seen in astrocytes, and both types of filament proteins are included in the perinuclear aggregates formed upon exposure of the cells to colcemid. In cerebellar...Continue Reading

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Citations

May 11, 2000·The Journal of Comparative Neurology·F Mercier, G I Hatton
Dec 7, 2000·Journal of Neuroscience Research·B K HaR W Burry
Mar 14, 2002·The Journal of Comparative Neurology·Rose HanburyJeffrey H Kordower
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Dec 1, 1991·Cellular and Molecular Neurobiology·P V SarthyJ Huang
Sep 1, 1992·Neurochemical Research·W T NortonC F Brosnan
Mar 1, 1991·Metabolic Brain Disease·S A Mikucki, M M Oblinger

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