Immunocytochemical demonstration of mineralocorticoid receptors in rat and human kidney.

Journal of Steroid Biochemistry
S E RundleJ W Funder

Abstract

Using a polyclonal antiserum against the hinge region of the recently cloned human mineralocorticoid receptor (MR) and indirect peroxidase immunohistochemistry, we have shown MR-like immunoreactivity (LI) in superficial nephron segments, including distal convoluted tubule, connecting piece and initial cortical collecting duct. The absence of staining in cells tentatively identified as intercalated cells on light microscopy was confirmed by pre-embedding electron microscopy. Though the intracellular distribution of immunostaining varied with the fixative used, the cellular distribution of MR-LI is in good general agreement with earlier micropuncture and autoradiographic studies.

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Jul 29, 2009·Current Opinion in Nephrology and Hypertension·Benjamin Ko, Robert S Hoover
Nov 1, 1991·Medicinal Research Reviews·W Sutanto, E R de Kloet
Sep 6, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Md Shahrier AminFrans H H Leenen
Jul 17, 2016·The Biochemical Journal·Abinash C MistryRobert S Hoover
Mar 5, 1998·The American Journal of Physiology·L J DaiG A Quamme
Jul 5, 2003·American Journal of Physiology. Renal Physiology·Rikke NørregaardBoye L Jensen
Feb 1, 1991·The American Journal of Physiology·N FarmanJ M Gasc

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