Immunocytochemical diagnosis of early myocardial ischaemic/hypoxic damage

Forensic Science International : Synergy
S LeadbeatterB Jasani


The sensitive and reliable dinitrophenyl (DNP) hapten sandwich staining (DHSS) procedure (B. Jasani et al., Virchows Arch (Pathol. Anat.), 406 (1985) 441-448) was used to study the distribution of immunoperoxidase staining seen with antibodies to seven protein markers in post-mortem heart tissue. This was obtained from 12 cases with macroscopic myocardial infarction and 17 cases without myocardial infarction (10 with and 7 without significant coronary artery atherosclerosis). The immunostaining patterns were compared with the appearances seen in adjacent sections stained by the routine haematoxylin and eosin (H & E) and phosphotungstic acid haematoxylin (PTAH) methods and a method previously recommended for the detection of early myocardial infarction, the haematoxylin basic fuchsin picric acid (HBFP) stain. Loss of immunostaining with an antibody to myoglobin was found to be a reliable and more objective marker of both early and established myocardial infarction compared with the histological stains. Antibodies to myosin, caeruloplasmin, C-reactive protein and pre-albumin gave similar but less reliable results, whilst those to complement factor C3b and alpha-1 anti-trypsin gave the least reliable results for early myocardial i...Continue Reading


Jul 1, 1976·Forensic Science·B Knight
May 1, 1979·Forensic Science International : Synergy·B Knight
May 1, 1987·Forensic Science International : Synergy·B Badir, B Knight
Mar 1, 1987·The American Journal of Forensic Medicine and Pathology·S B Karch
Aug 1, 1987·Journal of Clinical Pathology·G G Fechner, S Sivaloganathan
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·B JasaniA R Gibbs
Mar 1, 1985·Annals of Clinical Biochemistry·J M McCombA A Jadgey
Dec 1, 1969·The American Journal of Cardiology·R B Jennings
Jan 1, 1982·Annals of the New York Academy of Sciences·I M GoldsteinG Weissmann
Nov 1, 1984·The American Journal of Cardiology·H A KatusB A Khaw
Jan 1, 1983·British Heart Journal·H GilutzM R Quastel
Nov 1, 1980·The Journal of Clinical Investigation·R N PinckardM S Olson

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