Immunocytochemical differential diagnosis of adrenocortical neoplasms using the monoclonal antibody D11

Virchows Archiv. A, Pathological Anatomy and Histopathology
S SchröderG Klöppel

Abstract

The monoclonal antibody D11 is a valuable aid in the accurate typing of adrenal tumours as, in formalin-fixed, paraffin-embedding material, strong nuclear D11 positivity was observed only in adrenocortical cells in 190 neoplasms (including 100 adrenal tumours). This pattern was demonstrated for all zona glomerulosa cells in 27 normal adrenals and for the neoplastic cells of 15 adrenocortical adenomas derived from that zone, as judged from clinically evident hyperaldosteronism. Normal cells of zona fasciculata and reticularis also showed strong diffuse D11 immunostaining and the same nuclear plus cytoplasmic D11 reactivity was evident in 15 benign and malignant adrenocortical neoplasms derived from these zones, documented by hypercortisolism. Cytoplasmic and/or nuclear D11 staining made topohistogenetic typing possible in 15 non-functioning cortical tumours. D11 immunostaining gave negative results in 50 specimens containing normal, hyperplastic and neoplastic adrenomedullary cells. In addition, absence of D11 reactivity was recorded in 4 adrenal metastases of extra-adrenal carcinomas, 5 paragangliomas, 25 primary renal carcinomas and 59 of 60 primary thyroid carcinomas. D11 immunocytochemistry allows the accurate typing of beni...Continue Reading

References

Feb 1, 1988·European Journal of Pediatrics·M KrauseK Kruse
May 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·U BeisiegelR W Mahley
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P MattsonJ Kowal
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·H SasanoN Sasano
Jun 1, 1987·Klinische Wochenschrift·M DietelA Niendorf
Jan 1, 1987·Current Topics in Pathology. Ergebnisse Der Pathologie·P U Heitz
Jun 1, 1987·The American Journal of Surgical Pathology·J A RamsayE P de Harven
Sep 1, 1970·American Journal of Clinical Pathology·S C Sommers, J A Terzakis
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Feb 1, 1984·Clinical Endocrinology·B ShapiroW H Beierwaltes
Jul 15, 1983·European Journal of Biochemistry·R MyllyläK I Kivirikko

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Citations

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·S SchröderG Klöppel
Jul 13, 2002·Endocrine Pathology·Wolfgang SaegerChristina Reinhard
Apr 1, 1995·Endocrine Pathology·Carin BacklinJonas Rastad
Apr 6, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ricardo V Lloyd
Jan 9, 1998·The American Journal of Surgical Pathology·K J BusamA Jungbluth
Apr 1, 1996·Scandinavian Journal of Urology and Nephrology·K P DieckmannG Krolzig
Aug 3, 2006·Surgical Oncology Clinics of North America·Steven E RodgersNancy D Perrier
Feb 9, 2000·American Journal of Clinical Pathology·S J ShinR A DeLellis
Apr 3, 2001·European Journal of Clinical Investigation·W Saeger
Apr 15, 2004·Endocrine Reviews·Georg MansmannStefan R Bornstein
Dec 1, 1992·Endocrine Pathology·Theda C FöllerDieter K Lüdecke
Jun 27, 2003·The American Journal of Surgical Pathology·Jacqueline A WienekeClara S Heffess

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