Immunocytochemical distribution of ionotropic glutamate receptor subunits in the spinal cord of the rabbit

Journal of Chemical Neuroanatomy
A BonnotD Viala

Abstract

Several histochemical and physiological studies in the literature suggest that ionotropic glutamate receptors are involved in various sensory and motor control mechanisms at the spinal level. The present immunocytochemical study used three specific antibodies to GluR2,4, GluR5,6,7 and to NMDAR1 to differentiate between the regional distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) subtypes of glutamate receptors throughout the rabbit spinal cord. All of these immunoreactivities were prominent in the superficial dorsal horn and motor column. Each antibody gave rise to regionally specific immunostaining patterns but which were similar at all spinal levels. Numerous small neurons in superficial laminae were immunostained with GluR2,4 antibody while only neuropilar elements were immunostained with the two other antibodies. Cell bodies of the intermediate zone and fibres in the motor column were particularly densely immunostained with GluR5-7. Such an immunostaining pattern, which was particularly abundant with the GluR5-7 antibody, suggests the presence, at the spinal level, of an extensive population of neurons exhibiting a high density of kainate receptors. I...Continue Reading

References

Feb 25, 1992·European Journal of Pharmacology·J NäsströmC Post
Jul 1, 1992·Trends in Pharmacological Sciences·B Sommer, P H Seeburg
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N NakanishiN A Shneider
Oct 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I MerchenthalerF Gallyas
Nov 1, 1983·The Journal of Comparative Neurology·R L NahinG J Giesler
Jun 10, 1982·The Journal of Comparative Neurology·G F MartinA O Humbertson
Jun 1, 1995·The European Journal of Neuroscience·T R TölleW Zieglgänsberger
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J SiegelJ H Morrison
Apr 1, 1954·The Journal of Comparative Neurology·B REXED
Feb 1, 1962·The Journal of Comparative Neurology·H G KUYPERSJ W FARINHOLT

❮ Previous
Next ❯

Citations

Feb 19, 2003·Brain Research. Brain Research Reviews·Ruth Ruscheweyh, Jürgen Sandkühler
Jun 19, 2010·Progress in Neurobiology·Jun Chen, William R Lariviere
Mar 6, 2002·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Seiji OhtoriHideshige Moriya
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Dec 12, 2018·Journal of Chemical Neuroanatomy·Yasuro Atoji, Sonjoy Sarkar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.