Immunocytochemical evidence for an axonal localization of GABA in the optic nerves of rabbits, rats, and cats

Visual Neuroscience
P C Rogers, D V Pow

Abstract

We have examined, by light-microscopic immunocytochemistry, the distribution of GABA in the optic nerves of adult rabbits, rats, and cats. Within the optic nerves, immunoreactivity for GABA was restricted to a small subset of axons; some axons were strongly labelled, others weakly labelled, whilst most axons were unlabelled. Glia and other non-neuronal elements were always unlabelled. Our ability to detect GABA in optic nerve axons of adult mammals contrasts with previous reports that indicate a lack of GABA immunoreactivity in such axons. We suggest that this discrepancy may be due to the sensitivity of our immunocytochemical techniques which enable us to detect low concentrations of GABA.

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Citations

Aug 7, 1998·Brain Research. Developmental Brain Research·C H Lim, S M Ho
Sep 13, 2008·Progress in Neurobiology·María Cecilia AnguloEtienne Audinat
Mar 8, 2013·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael KalloniatisNiru Arunthavasothy
Apr 23, 2014·Glia·Arthur M ButtCarlos Matute
Aug 2, 2002·Journal of Neurobiology·Shane C D Ferguson, Sarah McFarlane
May 2, 2020·Science·Takuma SonodaTiffany M Schmidt
May 26, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mateo Vélez-FortMaría Cecilia Angulo
May 2, 2020·Science·Jennifer Ding, Wei Wei

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