PMID: 2496205Feb 1, 1989Paper

Immunocytochemical evidence for the localization of the GM1 ganglioside in carbonic anhydrase-containing and RT 97-immunoreactive rat primary sensory neurons

Journal of Neurocytology
B Robertson, G Grant

Abstract

Localization of GM1 ganglioside, the receptor for cholera toxin, and choleragenoid, which is the binding subunit of cholera toxin, was studied in the rat L5 dorsal root ganglion. Sections were incubated with choleragenoid and treated immunocytochemically. Choleragenoid-like immunoreactive cells were then examined for possible co-localization with carbonic anhydrase-like, RT 97 (antibody to neurofilament proteins), substance P-like, somatostatin-like and calcitonin gene-related peptide-like immunoreactivity and fluoride-resistant acid phosphatase (FRAP) activity, using adjacent sections. A subpopulation of dorsal root ganglion neurons exhibited choleragenoid-like immunoreactivity. The majority of these were medium-sized and large neurons. The strongest immunoreactivity was found in the area of the plasma membrane, but strong reactivity was also seen in the cytoplasm. The majority of the choleragenoid-like immunoreactive cells showed carbonic anhydrase-like and RT 97 immunoreactivity. Cells showing co-localization of choleragenoid-like and neuropeptide-like immunoreactivity or activity for FRAP were rarely observed. Our results suggest that the GM1 receptor is localized primarily on carbonic anhydrase-containing and RT 97-immunor...Continue Reading

References

Jan 1, 1989·Pflügers Archiv : European journal of physiology·P J WaddellP W Reeh
Mar 1, 1987·The Journal of Comparative Neurology·V WongL Guth
Jun 1, 1973·The Journal of Infectious Diseases·C A King, W E Van Heyningen
Aug 28, 1973·Biochemistry·P Cuatrecasas
Dec 1, 1983·Journal of Neurocytology·A L GanserM Willinger
Feb 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V WongL Guth
Sep 10, 1984·The Journal of Comparative Neurology·S N LawsonB H Anderton
Jan 1, 1984·Journal of Neuroscience Research·A L Ganser, D A Kirschner
Feb 1, 1983·Journal of Neurocytology·A RambourgA Beaudet
Jan 1, 1980·Developmental Biology·M Willinger, M Schachner
Mar 1, 1981·Bioscience Reports·J N Wood, B H Anderton
Apr 15, 1980·The Journal of Comparative Neurology·G Jancsó, E Király

❮ Previous
Next ❯

Citations

Feb 19, 1993·Brain Research. Developmental Brain Research·V MayeuxJ Valmier
Jan 24, 2002·Neurobiology of Aging·Esbjörn Bergman, Brun Ulfhake
Jan 28, 2016·Journal of Diabetes Investigation·Makoto Tsuda
Feb 3, 2007·Brain, Behavior, and Immunity·Simon Beggs, Michael W Salter
Jan 16, 2009·Developmental Science·Marco Del GiudiceChristian Keysers
Sep 3, 2009·Microscopy Research and Technique·Domenico RussoGiovanna Lalatta-Costerbosa
May 2, 2001·The Journal of Comparative Neurology·R J Phillips, T L Powley
Feb 8, 2020·International Journal of Molecular Sciences·Péter SánthaGábor Jancsó
Apr 8, 1990·The Journal of Comparative Neurology·I J Llewellyn-SmithA J Hodgson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.