PMID: 2958128Oct 15, 1987Paper

Immunocytochemical evidence of molecular photoreceptor markers in cerebellar medulloblastomas

Cancer
H W KorfI Gery

Abstract

With the use of antisera against bovine retinal S-antigen and bovine opsin the authors demonstrate that in cerebellar medulloblastomas certain tumor cells display immunocytochemical properties characteristic of retinal photoreceptors and pinealocytes. S-antigen-like and opsin-like immunoreactions occur in nine of 28 medulloblastomas investigated. All tumors displaying S-antigen-like immunoreactive neoplastic cells also contain opsin-like immunoreactive cells; however, the opsin-like immunoreactive cells were less frequent than the S-antigen-like immunoreactive cells throughout all positive cases. The immunoreactive cells displayed several long processes. Generally, both S-antigen and opsin-like immunoreactive cells considerably vary in number among individual tumors. The results indicate that certain neoplastic cells of medulloblastoma are capable of expression of photoreceptor-specific proteins and, thus, may be closely related to tumor cells of retinoblastoma and pineocytomas previously shown to bind antisera against retinal S-antigen and opsin. No S-antigen and opsin-like immunoreaction was found in malignant teratomas and germinomas of the pineal gland, oat cell tumors, astrocytomas, ependymomas, oligodendrogliomas, gliobla...Continue Reading

References

Jan 1, 1985·Cell and Tissue Research·H W KorfJ J Schalken
Jan 1, 1986·Acta Neuropathologica·H W KorfW Schachenmayr
Jan 1, 1973·International Archives of Allergy and Applied Immunology·C M Kalsow, W B Wacker

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Citations

Jan 1, 1988·Acta Neuropathologica·J M Bonnin, E Perentes
Aug 1, 1994·Critical Reviews in Oncology/hematology·W M Molenaar, J Q Trojanowski
May 28, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yoichi NakazatoSawai Jyunki
Sep 1, 1992·The British Journal of Ophthalmology·N IllumS Krabbe
May 6, 1991·FEBS Letters·W Glitscher, H Rüppel
Apr 27, 2010·Journal of Neuropathology and Experimental Neurology·Takahiro FukudaSaburo Saito
Jan 1, 1988·Annals of the New York Academy of Sciences·L J Rubinstein
Jan 1, 1990·Cancer·C RaoJ H Sher
Aug 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D SchifferM C Vigliani

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