Immunocytochemical evidence of molecular photoreceptor markers in cerebellar medulloblastomas
With the use of antisera against bovine retinal S-antigen and bovine opsin the authors demonstrate that in cerebellar medulloblastomas certain tumor cells display immunocytochemical properties characteristic of retinal photoreceptors and pinealocytes. S-antigen-like and opsin-like immunoreactions occur in nine of 28 medulloblastomas investigated. All tumors displaying S-antigen-like immunoreactive neoplastic cells also contain opsin-like immunoreactive cells; however, the opsin-like immunoreactive cells were less frequent than the S-antigen-like immunoreactive cells throughout all positive cases. The immunoreactive cells displayed several long processes. Generally, both S-antigen and opsin-like immunoreactive cells considerably vary in number among individual tumors. The results indicate that certain neoplastic cells of medulloblastoma are capable of expression of photoreceptor-specific proteins and, thus, may be closely related to tumor cells of retinoblastoma and pineocytomas previously shown to bind antisera against retinal S-antigen and opsin. No S-antigen and opsin-like immunoreaction was found in malignant teratomas and germinomas of the pineal gland, oat cell tumors, astrocytomas, ependymomas, oligodendrogliomas, gliobla...Continue Reading
Enzyme-linked immunosorbent assay for quantitative determination of the visual pigment rhodopsin in total-eye extracts
S-antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study
Localization of a uveitogenic soluble retinal antigen in the normal guinea pig eye by an indirect fluorescent antibody technique
Comparative study of a membrane protein. Characterization of bovine, rat, and frog visual pigments500
Neuron-associated class III beta-tubulin, tau, and MAP2 in the D-283 Med cell line and in primary explants of human medulloblastoma
Photoreceptor differentiation in cerebellar medulloblastoma: evidence for a functional photopigment and authentic S-antigen (arrestin)
Immunocytochemical demonstration of interphotoreceptor retinoid-binding protein in cerebellar medulloblastoma
Differentiation in medulloblastomas: correlation between the immunocytochemical demonstration of photoreceptor markers (S-antigen, rod-opsin) and the survival rate in 66 patients
Immunological detection of arrestin, a phototransduction regulatory protein, in the cytosol of nucleated erythrocytes
Studies of childhood brain tumors using immunohistochemistry and microwave technology: methodological considerations
Distribution of arrestin-like protein and beta-subunit of GTP-binding proteins in quail choroid plexuses
Primitive neuroectodermal tumors of the central nervous system in childhood: tumor biological aspects
Differential labeling of the pinealocytes and pineal interstitial cells by a series of monoclonal antibodies to human pineal body
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
Trilateral retinoblastoma variant indicative of the relevance of the retinoblastoma tumor-suppressor pathway to medulloblastomas in humans
Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors
Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies
Immunohistochemical characterization of primitive neuroectodermal tumors and their possible relationship to the stepwise ontogenetic development of the central nervous system. 2. Tumor studies
Neoplastic and immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.
Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.