PMID: 11456250Jul 18, 2001

Immunocytochemical features of lens after cataract tissue--signalling molecules (growth factors, cytokines, other signalling molecules), cytoskeleton proteins, cellular and extracellular matrix proteins

International Ophthalmology
T ShigemitsuS Arakaki

Abstract

We examined the immunocytochemical features of after cataract tissue and cataractous lens epithelium prior to cataract surgery and at the time of surgery. This study included 23 cases. Antibodies against the following antigens were used: epidermal growth factor (EGF), EGF receptor (EGF-R), fibroblast growth factor (FGF), FGF receptor (FGF-R), transforming growth factor (TGF)-beta, TGF-beta receptor II (TGF-beta -RII), insulin-like growth factor (IGF)II, platelet derived growth factor (PDGF)-AB, interleukin (IL)-6, IL-1 receptor II, tumor necrosis factor (TNF)-alpha, tissue plasminogen activator (TPA), prostaglandin (PG) E2, plasminogen activator inhibitor (PAI)-1, alpha smooth muscle actin (alpha-SMA), keratin, vimentin, myosin, fibronectin, laminin, types I, II, III, IV, V and VI collagen (Col), and lens epithelial cells (LECs). The following substances were present in posterior and anterior capsular fibrosis of after cataract: EGF, EGF-R, FGF, FGF-R, TGF-beta, TGF-beta-RII, IGF-II, PDGF-AB, IL-6, IL-1RII, TNF-alpha, PGE2, PAI-1, alpha-SMA, keratin, fibronectin, laminin, Type I col, Type II to VI col and LECs. Elschnig's pearls of after cataract expressed FGF-R, TNF-alpha, laminin and LECs. Soemmering's ring of after cataract ...Continue Reading

Citations

Feb 11, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yvonne de Jong-HesseGabriele E Lang
Jan 19, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C WertheimerK H Eibl-Lindner
Jul 29, 2010·Annals of Biomedical Engineering·R M Pedrigi, J D Humphrey
Jul 27, 2017·Vestnik oftalmologii·K S AvetisovI V Khaydukova
May 6, 2004·Journal of Biomedical Materials Research. Part a·Margaret D M EvansVéronique Migonney
May 29, 2010·Journal of Pediatric Ophthalmology and Strabismus·Inbal MichaelShulamit Levenberg
Apr 25, 2006·Journal of Cataract and Refractive Surgery·Juergen KampmeierGabriele E Lang
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·K S AvetisovP S Timashev

Related Concepts

Pseudoaphakia
Phakectomy
Cytoskeletal Proteins
Epithelial Cells
Eye Proteins
Growth Substances
Peroxidase-Antiperoxidase Complex Technique
Structure of Lens Capsule
Signal Transduction
Cytokine

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.